2026-04-05T12:42:44Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4810192025-08-31T17:48:10Zcom_2072_98col_2072_378192
RECERCAT author Perez-Rando, Marta author García-Martí, Gracián author Escarti, María José author Salgado-Pineda, Pilar author McKenna, Peter J. author Pomarol-Clotet, Edith author Grasa, Eva author Postiguillo, Alba author Corripio, Iluminada author Nacher, Juan author Universitat Autònoma de Barcelona 2024 Different lines of evidence indicate that the structure and physiology of the basal ganglia and the thalamus is disturbed in schizophrenia. However, it is unknown whether the volume and shape of these subcortical structures are affected in schizophrenia with auditory hallucinations (AH), a core positive symptom of the disorder. We took structural MRI from 63 patients with schizophrenia, including 36 patients with AH and 27 patients who had never experienced AH (NAH), and 51 matched healthy controls. We extracted volumes for the left and right thalamus, globus pallidus, putamen, caudate and nucleus accumbens. Shape analysis was also carried out. When comparing to controls, the volume of the right globus pallidus, thalamus, and putamen, was only affected in AH patients. The volume of the left putamen was also increased in individuals with AH, whereas the left globus pallidus was affected in both groups of patients. The shapes of right and left putamen and thalamus were also affected in both groups. The shape of the left globus pallidus was only altered in patients lacking AH, both in comparison to controls and to cases with AH. Lastly, the general PANSS subscale was correlated with the volume of the right thalamus, and the right and left putamen, in patients with AH. We have found volume and shape alterations of many basal ganglia and thalamus in patients with and without AH, suggesting in some cases a possible relationship between this positive symptom and these morphometric alterations. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/ Auditory hallucinations Schizophrenia Shape analysis Subcortical Volume analysis Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations Article