2026-04-13T14:18:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4802162025-08-31T17:31:12Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Riveiro Barciela, Mar author Carballal, Sabela author Diaz-Gonzalez, Álvaro author Mañosa i Ciria, Míriam author Gallego-Plazas, Javier author Cubiella, Joaquín author Jimenez-Fonseca, Paula author Varela, María author Menchen, Luís author Sangro, Bruno author Fernandez-Montes, Ana author Mesonero, Francisco author Rodriguez-Gandia, Miguel Ángel author Rivera, Fernando author Londono, María-Carlota author 2024 The development of the immune checkpoint inhibitors (ICI) is one of the most remarkable achievements in cancer therapy in recent years. However, their exponential use has led to an increase in immune-related adverse events (irAEs). Gastrointestinal and liver events encompass hepatitis, colitis and upper digestive tract symptoms accounting for the most common irAEs, with incidence rates varying from 2 % to 40 %, the latter in patients undergoing combined ICIs therapy. Based on the current scientific evidence derived from both randomized clinical trials and real-world studies, this statement document provides recommendations on the diagnosis, treatment and prognosis of the gastrointestinal and hepatic ICI-induced adverse events. Immunotherapy Immune checkpoint inhibitors Toxicity Hepatitis Colitis Drug-induced liver injury Immune-related adverse events Diarrhea Management of liver and gastrointestinal toxicity induced by immune checkpoint inhibitors : Position statement of the AEEH-AEG-SEPD-SEOM-GETECCU