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oai:recercat.cat:2072/4791562025-11-07T12:52:26Zcom_2072_98col_2072_378192

Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival : A cohort study Worm, Signe W. Bower, Mark Reiss, Peter Bonnet, Fabrice Law, Matthew Fätkenheuer, Gerd d'Arminio Monforte, Antonella Abrams, Donald I. Grulich, Andrew Fontas, Eric Kirk, Ole Furrer, Hansjakob De Wit, Stephane Phillips, Andrew Lundgren, Jens Sabin, Caroline A. Butcher, D. Delforge, M. Fanti, I. Franquet, X. Geffard, S. Gras, L. Helweg-Larsen, J. Hillebregt, M. Kamara, D. Kjær, J. Krum, E. McManus, H. Meidahl, P. Mocroft, A. Nielsen, J. Powderl, W. Rickenbach, M. Rode, R. Ryom, L. Salbøl Brandt, R. Schmidt Iversen, J. Shortman, N. Sjøl, A. Smith, C. Torres, F. Tverland, J. Wright, S. Zaheri, S. de Wolf, F. Smidt, J. Ristola, M. Katlama, C. Viard, J.P. Girard, P.M. Livrozet, J.M. Vanhems, P. Pradier, C. Dabis, F. Neau, D. Rockstroh, J. Schmidt, R. Degen, O. van Lunzen, J. Stellbrink, H.J. Staszewski, S. Bogner, J. Gargalianos, P. Kosmidis, J. Perdios, J. Xylomenos, G. Filandras, A. Karabatsaki, E. Panos, G. Sambatakou, H. Banhegyi, D. Mulcahy, F. Burke, M. Turner, D. Yust, I. Hassoun, G. Pollack, S. Maayan, S. Vella, S. Esposito, R. Mazeu, I. Mussini, C. Arici, C. Pristera, R. Gabbuti, A. Mazzotta, F. Lichtner, M. Vullo, V. Boer, K. Geerlings, S.E. Godfried, M.H. Kuijpers, T.W. Lange, J.M.A. Nellen, F.J.B. Pajkrt, D. Prins, J.M. Scherpbier, H.J. Vrouenraets, S.M.E. Wit, F.W.M.N. van Vugt, M. van der Meer, J.T.M. van der Poll, T. van der Valk, M. Chirianni, Antonio Gargiulo, Miriam Montesarchio, Enzo Antonucci, Giovanni Narciso, Pasquale Testa, Angela Vlassi, C. Zaccarelli, Mauro Castagna, Antonella Gianotti, Nicola Lazzarin, Adriano Galli, Massimo Ridolfo, Anna Lisa Rozentale, Baiba Zeltina, Indra Chaplinskas, Saulius A. Hemmer, Robert J. P. Staub, Thérèse Bruun, Johan Nikolai Maeland, Arild Ormaasen, Vidar Lowe, Selwyn H. Oude Lashof, Astrid M. L. Schreij, Gerrit S. Gasiorowski, Jacek Knysz, Brygida Bakowska, Elżbieta Horban, Andrzéj Flisiak, Robert Grzeszczuk, Anna Boron-Kaczmarska, Anna Parczewski, M. Pynka, Magdalena Beniowski, Marek Mularska, Elżbieta Trocha, Hanna Jablonowska, Elżbieta Malolepsza, Ewa Wojcik, Kamila Malgorzata Antunes, F. Caldeira, L. Doroana, M. Mansinho, K. Maltez, F. Bravenboer, B. Pronk, M.J.H. Duiculescu, D. Rakhmanova, A. Zakharova, Natalia Buzunova, Svetlana A. Jevtovic, Dorde Mokráš, Miloš Staneková, Danica Valkovicova Tomazic, Janez González-Lahoz, J. Labarga, Pablo Medrano, J. Soriano, V. Moreno, S. Rodriguez, J.M. Bravo, I. Clotet, B. Jou, A. Paredes, R. Puig, J. Tural, C. Gelinck, L.B.S. Nouwen, J.L. Rijnders, B.J.A. Schurink, C.A.M. Slobbe, L. Verbon, A. de Vries-Sluijs, T.E.M.S. van der Ende, M.E. van der Feltz, M. Gatell, J.M. Miró, J.M. Domingo, Pere Gutierrez, Mª del Mar Mateo, María Gracia Sambeat, Maria-Antònia Karlsson, A. Flamholc, L. Ledergerber, B. Weber, R. Cavassini, M. Francioli, P. Boffi, E. Hirschel, B. Battegay, M. Elzi, L. Chentsova, N. Kravchenko, E. Driessen, G.J.A. Hartwig, N.G. Frolov, V. Kutsyna, G. Servitskiy, S. Krasnov, M. Barton, S. Johnson, A.M. Mercey, D. Johnson, M.A. Murphy, M. Scullard, G. Fisher, M. Leen, C. Branger, J. Åkerlund, B. Morfeldt, L. Sundström., A. Thulin, G. Koppel, K. Ho̊kangård, C. Angarano, G. Antinori, A. Armignacco, O. Castelli, F. Cauda, R. Di Perri, G. Iardino, R. Ippolito, Giuseppe Moroni, M. Perno, C.F. Viale, P.L. Von Schlosser, F. Ammassari, A. Andreoni, M. Balotta, C. Bonfanti, P. Bonora, S. Borderi, M. Capobianchi, M.R. Ceccherini-Silberstein, F. Cinque, P. Cozzi-Lepri, Alessandro De Luca, A. Gervasoni, Cristina Girardi, Enrico Gori, Andrea Guaraldi, Giovanni Lo Caputo, Sergio Madeddu, Giuseppe Maggiolo, Franco Marchetti, Giulia Carla Marcotullio, Simone Monno, Laura Murri, Rita Puoti, Massimo Torti, Carlo Cicconi, Paola Formenti, Tiziana Galli, Luisa Lorenzini, Patrizia Costantini, Andrea Giacometti, Andrea R. Riva, Agostino Carrisa, C. Lazzari, Grazia Verucchi, Gabriella Schippers, E. F. Minardi, Cristina Abeli, Clara Quirino, Tiziana Manconi, Paolo Emilio Piano, Paola Falasca, Katia Vecchiet, Jacopo Segala, Daniela Sighinolfi, Laura Alessandrini, Anna Ida Cassola, Giovanni Mazzarello, Giovanni F. Piscopo, Rita Viscoli, G. Belvisi, Valeria Mastroianni, Claudio Maria Caramma, Ilaria Castelli, Paula Chiodera, Alessandro Alleman, Maarten A. Bouwhuis, Jolande W. Groeneveld, Paul Hendrik Pieter Bigoloni, Alba Carenzi, Laura Galli, Andrea Moioli, Mariacristina Piolini, Roberta Rizzardini, Giuliano Rossotti, Roberto Salpietro, Stefania Spagnuolo, Vincenzo Zucchi, P. Bisio, L. Lapadula, Giuseppe Abrescia, Nicola Guida, M. G. Baldelli, Franco Belfiori, Barbara Parruti, Giustino Ursini, Tamara Magnani, Giacomo Ursitti, Maria Alessandra Acinapura, Rosa Capozzi, Marcella Gallo, Luciana Libertone, Raffaella Nicastro, Emanuele Tebano, Gianpiero Tozzi, Valerio d'Avino, Alessandro Mura, María Stella Caramello, Pietro Orofino, Giancarlo Sciandra, Maurizio Soetekouw, Robert ten Kate, Reinier W. Manfrin, Vinicio Pellizzer, Gianpietro P. Bernard, Edwin J. Caissotti, Christophe Cua, Éric De Salvador-Guillouet, Francine Dellamonica, Pierre Dollet, K. Durant, Jacques M. Ferrando, Sarah Mondain-Miton, Véronique Naqvi, Alissa Perbost, Isabelle Pillet, Sylvie Prouvost-Keller, Bernard Pugliese, Pascale Rahelinirina, Véronique Roger, Pierre-Marie Barth, Jürgen Bernasconi, Enos Böni, Jürg Bucher, Heíner Claudins C. Burton-Jeangros, Claudine Calmy, Alexandra Cellerai, Cristina Dubs, Rolf W. Egger, Matthias Fehr, Jan Sven Flepp, Markus J. Fux, Christoph Andreas Gorgievski, Meri Günthard, Hüldrych Fritz Hasse, Barbara Katharina Hirsch, Hans H. Hösli, Irene Kahlert, Christian R. Kaiser, Laurent K. Keiser, Olivia Kind, Christian H. Klimkait, Thomas Kovari, Helen Martinetti, Gladys Martinez de Tejada, Begoña Müller, Nicolas J. Nadal, David Javier Pantaleo, Giuseppe P. Rauch, Andri Regenass, Stephan Rudin, Christoph Schmid, Patrick Schöni-Affolter, Franziska Schüpbach, Jörg Rg Schultze, Detlev Speck, Roberto F. Taffé, Patrick Telenti, Amalio Trkola, Alexandra Vernazza, Pietro Luigi Yerly, Sabine T. B. D. von Wyl, Viktor Arend, Sandra M. Jolink, Hetty Kroon, Frank P. de Boer, Mark G. J. van Dissel, Jaap Tamino J. van Nieuwkoop, Cees van den Broek, Pieter J. Pogany, Katalin den Hollander, Jan G. Kortmann, Willemijn van Twillert, Gitte Leyten, Eliane Madeleine Sophie Vriesendorp, Robert Kootstra, Gert Jan ten Napel, Chris H. H. Blok, Willem L. Brinkman, Kees Frissen, P. H. Jos Schouten, Wilhelmina E. M. Ineke van den Berk, Guido E. L. Brouwer, Annemarie E. Juttmann, Job R. van Kasteren, Marjo E. E. Lettinga, Kamilla D. Veenstra, Jan Mulder, Jan Willem A. Smit, Patrick M. Weijer, Sebastiaan van Gorp, E. C. Verhagen, Dominique W. M. van Eeden, Arne Doedens, Rienus A. Scholvinck, Elisabeth H. Sprenger, Herman G. Stek, Cari J. van Assen, Sander Brouwer, A. M. Dofferhoff, A. S. M. Keuter, Monique M. Koopmans, Peter P. de Groot, Ronald ter Hofstede, Hadewych J. M. T. van der Flier, Michiel van der Ven, André J. A. M. Arends, Joop E. A. Ellerbroek, Pauline Marit Hoepelman, Andy I. M. Jaspers, Christiaan A. J. J. Maarschalk-Ellerbroek, L. J. Mudrikova, Tania Oosterheert, Jan Jelrik Peters, Edgar J. G. Schneider, Margaret M. E. Wassenberg, Marjan W. M. van der Hilst, Jeroen Bierman, Wouter F. W. Claessen, Frans A. P. Danner, Sven A. Perenboom, Roos M. bij de Vaate, E. A. de Jong, E. V. de Vocht, J. W. M. M. van Agtmael, Michiel A. Geelen, Sibyl P. M. Wolfs, Tom F. W. Gisolf, Elisabeth H. Richter, J. P. van der Berg, Christine Stegeman, Jan Arend van den Berge, Marcel Polée, Marco B. van Houte, Dennis P. F. van Vonderen, Marit G. A. Duits, Ashley J. Winkel, Carel N. Chêne, Geneviève Dupon, Michel Fleury, Hervè J. A. Lacoste, Denis Malvy, Denis Jean Marie Mercié, Patrick Morlat, Philippe Pellegrin, I. Pellegrin, Jean Luc J. Thiébaut, Rodolphe Titier, Karine Bruyand, Mathias Lawson-Ayayi, Sylvie Wittkop, Linda Bernard, Noëlle Bonnal, F. Caunègre, L. Cazanave, Charles J. Ceccaldi, Joël Chambon, D. Chossat, Isabelle Courtaud, K. Dauchy, Frédéric Antoine De Witte, Sten A. Duffau, Pierre Dupont, Alain Dutronc, Hervé Farbos, Sophie Gaboriau, Valérie Gemain, M. C. Gerard, Yann Greib, Carinne Hessamfar, Mojgan Bonarek Lafarie-Castet, Sabine Lataste, Ph. Lazaro, Estibaliz Longy-Boursier, Maïté Meraud, J. P. Monlun, Eric Sierra Ochoa, Adriana Pistone, Thierry Ragnaud, Jean Marie Receveur, Marie Catherine Roger-Schmeltz, Julien Tchamgoué, Serge Thibaut, Pierre Vandenhende, Marianne Viallard, Jean François Moreau, Jean François Pellegrin, Isabelle Lafon, Marie Édith Masquelier, Bernard Trimoulet, Pascale Breilh, Dominique Haramburu, Françoise Miremont-Salamé, Ghada Blaizeau, Marie Josée D'Ivernois, Christophe Decoin, Madeleine Delaune, Jean Delveaux, Sandrine Hanappier, C. Leleux, Olivier Sicard, X. Uwamaliya-Nziyumvira, B. Leray, J. Palmer, Gilles Touchard, Dominique Baker, David Alfred Bendall, C. Bloch, Mark Theo Carr, Andrew D. Cooper, David A. Franic, Teo Petoumenos, Kathy Vale, Robyn J. Edwards, Simon G. Hoy, Jennifer F. Moore, Richard James Nicholson, Janet K. A. Roth, Norman J. Watson, Kerrie M. Chuah, John C.P. Ngieng, M. Nolan, David A. Skett, J. Cadafalch, Joseph Calvo Rojas, Gonzalo Codina Jané, C. J. Del Cacho, E. Fuster, Montserrat Gatell, Jose Maria Mateu, Silvia Sirera, Guillem Vaqué, A. Clumeck, Nathan N. De Wit, Stéphane A. Gennotte, Anne Francoise Gerard, Michèle Kabeya, Kabamba Konopnicki, Deborah Libois, Agnès Martin, Charles Necsoi, Coca Valentina Payen, Marie Christine Semaille, Pascal Van Laethem, Yves Bartsch, G. El-Sadr, W. M. Neaton, James D. Thompson, G. Wentworth, David E. Luskin-Hawk, Roberta L. Telzak, Edward E. Cohn, David L. Markowitz, Norman P. Arduino, Roberto C. Mushatt, David M. Friedland, Gerald H. Perez, Gloria Tedaldi, Ellen M. Fisher, Evelyn J. Gordin, Fred M. Crane, L.R. Sampson, James H. Baxter, J. D. Fischer, Aurelie H. Grint, Daniel J. Kjaer, Jesper Kowalska, Justyna Peters, Lars Podlekareva, Daria Reekie, Joanne Elias, C. Losso, Marcelo Horacio Vetter, Norbert Zangerle, Robert Karpov, Igor Alexandrovich Vassilenko, Anna Mitsura, Viktar M. Suetnov, Oleg Colebunders, Robert Leon Vandekerckhove, Linos Hadziosmanovic, Vesnadarjan Kostov, Kostadin Begovac, Josip Jilich, David Machala, Ladislav Sedlacek, Dalibor Benfield, Thomas Kronborg, Gritte Larsen, Mette Vang Gerstoft, Jan Hansen, Ann Britt E. Katzenstein, Terese Lea Skinhøj, Peter Pedersen, Court K. Ostergaard, Lars Jørgen Zilmer, Kai Universitat Autònoma de Barcelona HIV Incidence Non-AIDS defining cancers Prognosis Trends Background: Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.Methods: Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.Results: Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.Conclusions: The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC. © 2013 Worm et al.; licensee BioMed Central Ltd. 2013 Article BMC Infectious diseases ; Vol. 13 Núm. 1 (september 2013), p. 471 open access Aquest document està subjecte a una llicència d'ús Creative Commons. 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