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00925njm 22002777a 4500 dc Worm, Signe W. author Bower, Mark author Reiss, Peter author Bonnet, Fabrice author Law, Matthew author Fätkenheuer, Gerd author d'Arminio Monforte, Antonella author Abrams, Donald I. author Grulich, Andrew author Fontas, Eric author Kirk, Ole author Furrer, Hansjakob author De Wit, Stephane author Phillips, Andrew author Lundgren, Jens author Sabin, Caroline A. author Butcher, D. author Delforge, M. author Fanti, I. author Franquet, X. author Geffard, S. author Gras, L. author Helweg-Larsen, J. author Hillebregt, M. author Kamara, D. author Kjær, J. author Krum, E. author McManus, H. author Meidahl, P. author Mocroft, A. author Nielsen, J. author Powderl, W. author Rickenbach, M. author Rode, R. author Ryom, L. author Salbøl Brandt, R. author Schmidt Iversen, J. author Shortman, N. author Sjøl, A. author Smith, C. author Torres, F. author Tverland, J. author Wright, S. author Zaheri, S. author de Wolf, F. author Smidt, J. author Ristola, M. author Katlama, C. author Viard, J.P. author Girard, P.M. author Livrozet, J.M. author Vanhems, P. author Pradier, C. author Dabis, F. author Neau, D. author Rockstroh, J. author Schmidt, R. author Degen, O. author van Lunzen, J. author Stellbrink, H.J. author Staszewski, S. author Bogner, J. author Gargalianos, P. author Kosmidis, J. author Perdios, J. author Xylomenos, G. author Filandras, A. author Karabatsaki, E. author Panos, G. author Sambatakou, H. author Banhegyi, D. author Mulcahy, F. author Burke, M. author Turner, D. author Yust, I. author Hassoun, G. author Pollack, S. author Maayan, S. author Vella, S. author Esposito, R. author Mazeu, I. author Mussini, C. author Arici, C. author Pristera, R. author Gabbuti, A. author Mazzotta, F. author Lichtner, M. author Vullo, V. author Boer, K. author Geerlings, S.E. author Godfried, M.H. author Kuijpers, T.W. author Lange, J.M.A. author Nellen, F.J.B. author Pajkrt, D. author Prins, J.M. author Scherpbier, H.J. author Vrouenraets, S.M.E. author Wit, F.W.M.N. author van Vugt, M. author van der Meer, J.T.M. author van der Poll, T. author van der Valk, M. author Chirianni, Antonio author Gargiulo, Miriam author Montesarchio, Enzo author Antonucci, Giovanni author Narciso, Pasquale author Testa, Angela author Vlassi, C. author Zaccarelli, Mauro author Castagna, Antonella author Gianotti, Nicola author Lazzarin, Adriano author Galli, Massimo author Ridolfo, Anna Lisa author Rozentale, Baiba author Zeltina, Indra author Chaplinskas, Saulius A. author Hemmer, Robert J. P. author Staub, Thérèse author Bruun, Johan Nikolai author Maeland, Arild author Ormaasen, Vidar author Lowe, Selwyn H. author Oude Lashof, Astrid M. L. author Schreij, Gerrit S. author Gasiorowski, Jacek author Knysz, Brygida author Bakowska, Elżbieta author Horban, Andrzéj author Flisiak, Robert author Grzeszczuk, Anna author Boron-Kaczmarska, Anna author Parczewski, M. author Pynka, Magdalena author Beniowski, Marek author Mularska, Elżbieta author Trocha, Hanna author Jablonowska, Elżbieta author Malolepsza, Ewa author Wojcik, Kamila Malgorzata author Antunes, F. author Caldeira, L. author Doroana, M. author Mansinho, K. author Maltez, F. author Bravenboer, B. author Pronk, M.J.H. author Duiculescu, D. author Rakhmanova, A. author Zakharova, Natalia author Buzunova, Svetlana A. author Jevtovic, Dorde author Mokráš, Miloš author Staneková, Danica Valkovicova author Tomazic, Janez author González-Lahoz, J. author Labarga, Pablo author Medrano, J. author Soriano, V. author Moreno, S. author Rodriguez, J.M. author Bravo, I. author Clotet, B. author Jou, A. author Paredes, R. author Puig, J. author Tural, C. author Gelinck, L.B.S. author Nouwen, J.L. author Rijnders, B.J.A. author Schurink, C.A.M. author Slobbe, L. author Verbon, A. author de Vries-Sluijs, T.E.M.S. author van der Ende, M.E. author van der Feltz, M. author Gatell, J.M. author Miró, J.M. author Domingo, Pere author Gutierrez, Mª del Mar author Mateo, María Gracia author Sambeat, Maria-Antònia author Karlsson, A. author Flamholc, L. author Ledergerber, B. author Weber, R. author Cavassini, M. author Francioli, P. author Boffi, E. author Hirschel, B. author Battegay, M. author Elzi, L. author Chentsova, N. author Kravchenko, E. author Driessen, G.J.A. author Hartwig, N.G. author Frolov, V. author Kutsyna, G. author Servitskiy, S. author Krasnov, M. author Barton, S. author Johnson, A.M. author Mercey, D. author Johnson, M.A. author Murphy, M. author Scullard, G. author Fisher, M. author Leen, C. author Branger, J. author Åkerlund, B. author Morfeldt, L. author Sundström., A. author Thulin, G. author Koppel, K. author Ho̊kangård, C. author Angarano, G. author Antinori, A. author Armignacco, O. author Castelli, F. author Cauda, R. author Di Perri, G. author Iardino, R. author Ippolito, Giuseppe author Moroni, M. author Perno, C.F. author Viale, P.L. author Von Schlosser, F. author Ammassari, A. author Andreoni, M. author Balotta, C. author Bonfanti, P. author Bonora, S. author Borderi, M. author Capobianchi, M.R. author Ceccherini-Silberstein, F. author Cinque, P. author Cozzi-Lepri, Alessandro author De Luca, A. author Gervasoni, Cristina author Girardi, Enrico author Gori, Andrea author Guaraldi, Giovanni author Lo Caputo, Sergio author Madeddu, Giuseppe author Maggiolo, Franco author Marchetti, Giulia Carla author Marcotullio, Simone author Monno, Laura author Murri, Rita author Puoti, Massimo author Torti, Carlo author Cicconi, Paola author Formenti, Tiziana author Galli, Luisa author Lorenzini, Patrizia author Costantini, Andrea author Giacometti, Andrea R. author Riva, Agostino author Carrisa, C. author Lazzari, Grazia author Verucchi, Gabriella author Schippers, E. F. author Minardi, Cristina author Abeli, Clara author Quirino, Tiziana author Manconi, Paolo Emilio author Piano, Paola author Falasca, Katia author Vecchiet, Jacopo author Segala, Daniela author Sighinolfi, Laura author Alessandrini, Anna Ida author Cassola, Giovanni author Mazzarello, Giovanni F. author Piscopo, Rita author Viscoli, G. author Belvisi, Valeria author Mastroianni, Claudio Maria author Caramma, Ilaria author Castelli, Paula author Chiodera, Alessandro author Alleman, Maarten A. author Bouwhuis, Jolande W. author Groeneveld, Paul Hendrik Pieter author Bigoloni, Alba author Carenzi, Laura author Galli, Andrea author Moioli, Mariacristina author Piolini, Roberta author Rizzardini, Giuliano author Rossotti, Roberto author Salpietro, Stefania author Spagnuolo, Vincenzo author Zucchi, P. author Bisio, L. author Lapadula, Giuseppe author Abrescia, Nicola author Guida, M. G. author Baldelli, Franco author Belfiori, Barbara author Parruti, Giustino author Ursini, Tamara author Magnani, Giacomo author Ursitti, Maria Alessandra author Acinapura, Rosa author Capozzi, Marcella author Gallo, Luciana author Libertone, Raffaella author Nicastro, Emanuele author Tebano, Gianpiero author Tozzi, Valerio author d'Avino, Alessandro author Mura, María Stella author Caramello, Pietro author Orofino, Giancarlo author Sciandra, Maurizio author Soetekouw, Robert author ten Kate, Reinier W. author Manfrin, Vinicio author Pellizzer, Gianpietro P. author Bernard, Edwin J. author Caissotti, Christophe author Cua, Éric author De Salvador-Guillouet, Francine author Dellamonica, Pierre author Dollet, K. author Durant, Jacques M. author Ferrando, Sarah author Mondain-Miton, Véronique author Naqvi, Alissa author Perbost, Isabelle author Pillet, Sylvie author Prouvost-Keller, Bernard author Pugliese, Pascale author Rahelinirina, Véronique author Roger, Pierre-Marie author Barth, Jürgen author Bernasconi, Enos author Böni, Jürg author Bucher, Heíner Claudins C. author Burton-Jeangros, Claudine author Calmy, Alexandra author Cellerai, Cristina author Dubs, Rolf W. author Egger, Matthias author Fehr, Jan Sven author Flepp, Markus J. author Fux, Christoph Andreas author Gorgievski, Meri author Günthard, Hüldrych Fritz author Hasse, Barbara Katharina author Hirsch, Hans H. author Hösli, Irene author Kahlert, Christian R. author Kaiser, Laurent K. author Keiser, Olivia author Kind, Christian H. author Klimkait, Thomas author Kovari, Helen author Martinetti, Gladys author Martinez de Tejada, Begoña author Müller, Nicolas J. author Nadal, David Javier author Pantaleo, Giuseppe P. author Rauch, Andri author Regenass, Stephan author Rudin, Christoph author Schmid, Patrick author Schöni-Affolter, Franziska author Schüpbach, Jörg Rg author Schultze, Detlev author Speck, Roberto F. author Taffé, Patrick author Telenti, Amalio author Trkola, Alexandra author Vernazza, Pietro Luigi author Yerly, Sabine T. B. D. author von Wyl, Viktor author Arend, Sandra M. author Jolink, Hetty author Kroon, Frank P. author de Boer, Mark G. J. author van Dissel, Jaap Tamino J. author van Nieuwkoop, Cees author van den Broek, Pieter J. author Pogany, Katalin author den Hollander, Jan G. author Kortmann, Willemijn author van Twillert, Gitte author Leyten, Eliane Madeleine Sophie author Vriesendorp, Robert author Kootstra, Gert Jan author ten Napel, Chris H. H. author Blok, Willem L. author Brinkman, Kees author Frissen, P. H. Jos author Schouten, Wilhelmina E. M. Ineke author van den Berk, Guido E. L. author Brouwer, Annemarie E. author Juttmann, Job R. author van Kasteren, Marjo E. E. author Lettinga, Kamilla D. author Veenstra, Jan author Mulder, Jan Willem A. author Smit, Patrick M. author Weijer, Sebastiaan author van Gorp, E. C. author Verhagen, Dominique W. M. author van Eeden, Arne author Doedens, Rienus A. author Scholvinck, Elisabeth H. author Sprenger, Herman G. author Stek, Cari J. author van Assen, Sander author Brouwer, A. M. author Dofferhoff, A. S. M. author Keuter, Monique M. author Koopmans, Peter P. author de Groot, Ronald author ter Hofstede, Hadewych J. M. T. author van der Flier, Michiel author van der Ven, André J. A. M. author Arends, Joop E. A. author Ellerbroek, Pauline Marit author Hoepelman, Andy I. M. author Jaspers, Christiaan A. J. J. author Maarschalk-Ellerbroek, L. J. author Mudrikova, Tania author Oosterheert, Jan Jelrik author Peters, Edgar J. G. author Schneider, Margaret M. E. author Wassenberg, Marjan W. M. author van der Hilst, Jeroen author Bierman, Wouter F. W. author Claessen, Frans A. P. author Danner, Sven A. author Perenboom, Roos M. author bij de Vaate, E. A. author de Jong, E. V. author de Vocht, J. W. M. M. author van Agtmael, Michiel A. author Geelen, Sibyl P. M. author Wolfs, Tom F. W. author Gisolf, Elisabeth H. author Richter, J. P. author van der Berg, Christine author Stegeman, Jan Arend author van den Berge, Marcel author Polée, Marco B. author van Houte, Dennis P. F. author van Vonderen, Marit G. A. author Duits, Ashley J. author Winkel, Carel N. author Chêne, Geneviève author Dupon, Michel author Fleury, Hervè J. A. author Lacoste, Denis author Malvy, Denis Jean Marie author Mercié, Patrick author Morlat, Philippe author Pellegrin, I. author Pellegrin, Jean Luc J. author Thiébaut, Rodolphe author Titier, Karine author Bruyand, Mathias author Lawson-Ayayi, Sylvie author Wittkop, Linda author Bernard, Noëlle author Bonnal, F. author Caunègre, L. author Cazanave, Charles J. author Ceccaldi, Joël author Chambon, D. author Chossat, Isabelle author Courtaud, K. author Dauchy, Frédéric Antoine author De Witte, Sten A. author Duffau, Pierre author Dupont, Alain author Dutronc, Hervé author Farbos, Sophie author Gaboriau, Valérie author Gemain, M. C. author Gerard, Yann author Greib, Carinne author Hessamfar, Mojgan Bonarek author Lafarie-Castet, Sabine author Lataste, Ph. author Lazaro, Estibaliz author Longy-Boursier, Maïté author Meraud, J. P. author Monlun, Eric author Sierra Ochoa, Adriana author Pistone, Thierry author Ragnaud, Jean Marie author Receveur, Marie Catherine author Roger-Schmeltz, Julien author Tchamgoué, Serge author Thibaut, Pierre author Vandenhende, Marianne author Viallard, Jean François author Moreau, Jean François author Pellegrin, Isabelle author Lafon, Marie Édith author Masquelier, Bernard author Trimoulet, Pascale author Breilh, Dominique author Haramburu, Françoise author Miremont-Salamé, Ghada author Blaizeau, Marie Josée author D'Ivernois, Christophe author Decoin, Madeleine author Delaune, Jean author Delveaux, Sandrine author Hanappier, C. author Leleux, Olivier author Sicard, X. author Uwamaliya-Nziyumvira, B. author Leray, J. author Palmer, Gilles author Touchard, Dominique author Baker, David Alfred author Bendall, C. author Bloch, Mark Theo author Carr, Andrew D. author Cooper, David A. author Franic, Teo author Petoumenos, Kathy author Vale, Robyn J. author Edwards, Simon G. author Hoy, Jennifer F. author Moore, Richard James author Nicholson, Janet K. A. author Roth, Norman J. author Watson, Kerrie M. author Chuah, John C.P. author Ngieng, M. author Nolan, David A. author Skett, J. author Cadafalch, Joseph author Calvo Rojas, Gonzalo author Codina Jané, C. J. author Del Cacho, E. author Fuster, Montserrat author Gatell, Jose Maria author Mateu, Silvia author Sirera, Guillem author Vaqué, A. author Clumeck, Nathan N. author De Wit, Stéphane A. author Gennotte, Anne Francoise author Gerard, Michèle author Kabeya, Kabamba author Konopnicki, Deborah author Libois, Agnès author Martin, Charles author Necsoi, Coca Valentina author Payen, Marie Christine author Semaille, Pascal author Van Laethem, Yves author Bartsch, G. author El-Sadr, W. M. author Neaton, James D. author Thompson, G. author Wentworth, David E. author Luskin-Hawk, Roberta L. author Telzak, Edward E. author Cohn, David L. author Markowitz, Norman P. author Arduino, Roberto C. author Mushatt, David M. author Friedland, Gerald H. author Perez, Gloria author Tedaldi, Ellen M. author Fisher, Evelyn J. author Gordin, Fred M. author Crane, L.R. author Sampson, James H. author Baxter, J. D. author Fischer, Aurelie H. author Grint, Daniel J. author Kjaer, Jesper author Kowalska, Justyna author Peters, Lars author Podlekareva, Daria author Reekie, Joanne author Elias, C. author Losso, Marcelo Horacio author Vetter, Norbert author Zangerle, Robert author Karpov, Igor Alexandrovich author Vassilenko, Anna author Mitsura, Viktar M. author Suetnov, Oleg author Colebunders, Robert Leon author Vandekerckhove, Linos author Hadziosmanovic, Vesnadarjan author Kostov, Kostadin author Begovac, Josip author Jilich, David author Machala, Ladislav author Sedlacek, Dalibor author Benfield, Thomas author Kronborg, Gritte author Larsen, Mette Vang author Gerstoft, Jan author Hansen, Ann Britt E. author Katzenstein, Terese Lea author Skinhøj, Peter author Pedersen, Court K. author Ostergaard, Lars Jørgen author Zilmer, Kai author Universitat Autònoma de Barcelona author 2013 Background: Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.Methods: Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.Results: Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.Conclusions: The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC. © 2013 Worm et al.; licensee BioMed Central Ltd. HIV Incidence Non-AIDS defining cancers Prognosis Trends Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival : A cohort study