2026-04-18T00:28:29Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4785812025-10-28T12:25:26Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Brassetti, Aldo author Anceschi, Umberto author Cozzi, Gabriele author Chavarriaga, Julian author Gavrilov, Pavel author Gaya Sopena, Josep Maria author Bove, Alfredo Maria author Prata, Francesco author Ferriero, Mariaconsiglia author Mastroianni, Riccardo author Misuraca, Leonardo author Tuderti, Gabriele author Torregiani, Giulia author Covotta, Marco author Camacho, Diego author Musi, Gennaro author Varela, Rodolfo author Breda, Alberto author De Cobelli, Ottavio author Simone, Giuseppe author Universitat Autònoma de Barcelona author 2023 To optimize results reporting after penile cancer (PC) surgery, we proposed a Tetrafecta and assessed its ability to predict overall survival (OS) probabilities. A purpose-built multicenter, multi-national database was queried for stage I-IIIB PC, requiring inguinal lymphadenectomy (ILND), from 2015 onwards. Kaplan-Meier (KM) method assessed differences in OS between patients achieving Tetrafecta or not. Univariable and multivariable regression analyses identified its predictors. A total of 154 patients were included in the analysis. The 45 patients (29%) that achieved the Tetrafecta were younger (59 vs. 62 years; p = 0.01) and presented with fewer comorbidities (ASA score ≥ 3: 0% vs. 24%; p < 0.001). Although indicated, ILND was omitted in 8 cases (5%), while in 16, a modified template was properly used. Although median LNs yield was 17 (IQR: 11-27), 35% of the patients had <7 nodes retrieved from the groin. At Kaplan-Maier analysis, the Tetrafecta cohort displayed significantly higher OS probabilities (Log Rank = 0.01). Uni- and multivariable logistic regression analyses identified age as the only independent predictor of Tetrafecta achievement (OR: 0.97; 95%CI: 0.94-0.99; p = 0.04). Our Tetrafecta is the first combined outcome to comprehensively report results after PC surgery. It is widely applicable, based on standardized and reproducible variables and it predicts all-cause mortality. Tetrafecta Inguinal lymphadenectomy Penile cancer Surgical quality Survival Combined Reporting of Surgical Quality and Cancer Control after Surgical Treatment for Penile Tumors with Inguinal Lymph Node Dissection : The Tetrafecta Achievement