2026-04-13T02:15:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4782102025-10-27T12:42:08Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Loeb, Eduardo author Zock, Jan-Paul author Miravitlles, Marc author Rodríguez, Esther author Kromhout, Hans author Vermeulen, Roel author Soler-Cataluña, Juan José author Soriano, Joan B.. author García-Rio, Francisco author de Lucas-Ramos, Pilar author Alfageme, Inmaculada author Casanova, Ciro author Rodríguez González-Moro, José Miguel author Ancochea, Julio author Cosio, Borja G author Ferrer Sancho, Jaume author 2024 Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19-4.22), biological dust (OR 3.01 95% CI 1.22-7.45), gases/fumes (OR 2.49 95% CI 1.20-5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21-16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42-24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16-15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population. Chronic obstructive pulmonary disease COPD Occupational exposures Job exposure matrix JEM Computed tomography Emphysema Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population