2026-04-14T03:13:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4778862025-08-31T17:28:08Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Corral Pujol, Marta author Arpa, Berta author Rosell-Mases, Estela author Egia-Mendikute, Leire author Mora, Conchi author Stratmann, Thomas author Sanchez, Alex author Casanovas, Anna author Esquerda, Josep Enric author Mauricio Puente, Dídac author Vives Pi, Marta author Verdaguer, J. author Universitat Autònoma de Barcelona author 2023 During the development of Autoimmune Diabetes (AD) an autoimmune attack against the Peripheral Nervous System occurs. To gain insight into this topic, analyses of Dorsal Root Ganglia (DRG) from Non-Obese Diabetic (NOD) mice were carried out. Histopathological analysis by electron and optical microscopy in DRG samples, and mRNA expression analyzes by the microarray technique in DRG and blood leukocyte samples from NOD and C57BL/6 mice were performed. The results showed the formation of cytoplasmic vacuoles in DRG cells early in life that could be related to a neurodegenerative process. In view of these results, mRNA expression analyses were conducted to determine the cause and/or the molecules involved in this suspected disorder. The results showed that DRG cells from NOD mice have alterations in the transcription of a wide range of genes, which explain the previously observed alterations. In addition, differences in the transcription genes in white blood cells were also detected. Taken together, these results indicate that functional defects are not only seen in beta cells but also in DRG in NOD mice. These results also indicate that these defects are not a consequence of the autoimmune process that takes place in NOD mice and suggest that they may be involved as triggers for its development. NOD mouse/mice Autoimmune diseases/disorders Dorsal root ganglion Neural regulation Neurodegeneration Parasympathetic function Type 1 diabetes NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development