2026-04-17T03:04:52Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4767832024-12-05T05:08:10Zcom_2072_98col_2072_378192
RECERCAT author Toscano-Prat, Clara author Martínez-González, José Pablo author Guasch-Jiménez, Marina author Ramos-Pachón, Anna author Martí-Fàbregas, Joan author Blanco-Sanroman, Nerea author Coronel-Coronel, Melissa Fabiola author Domine, María Constanza author Martínez-Domeño, Alejandro author Prats-Sánchez, Luis Antonio author Marín-Bueno, Rebeca author Aguilera-Simón, Ana author Lambea-Gil, Álvaro author Ezcurra-Díaz, Garbiñe author Camps-Renom, Pol author Universitat Autònoma de Barcelona 2024 In patients with acute ischaemic stroke (AIS), haemorrhagic transformation (HT) following endovascular treatment (EVT) is associated with poor functional outcome. However, the impact of asymptomatic HT, not linked to neurological deterioration in the acute phase, is unknown. We aimed to investigate the impact of asymptomatic PH1 (aPH1) and PH2 (aPH2) subtypes of HT on the functional outcome of patients treated with EVT. We conducted a retrospective study of patients with AIS who were consecutively admitted to our comprehensive stroke centre between January 2019 and December 2022, and who underwent EVT. We collected clinical, radiological, and procedural data. HTs were categorized according to the Heidelberg classification. The primary outcome was the shift on the modified Rankin Scale (mRS) at 3 months of follow-up. We performed bivariate and multivariable ordinal regression analyses to test the association between aPH1/aPH2 and the primary outcome. We included 314 patients (mean age = 72.5 years [SD = 13.6], 171 [54.5%] women). We detected 54 (17.2%) patients with HT; 23 (7.3%) were classified as PH2 (11 asymptomatic) and 17 (5.4%) as PH1 (16 asymptomatic). The adjusted common odds ratio for aPH2 of worsening 1 point on the 3-month mRS was 3.32 (95% confidence interval = 1.16-9.57, p = 0.026). No association was observed for aPH1. aPH2 was also independently associated with lower odds of achieving a favourable outcome (mRS = 0-2). Neither aPH1 nor aPH2 was associated with mortality. In patients with AIS treated with EVT, aPH2 is independently associated with unfavourable functional outcome. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by-nc/4.0/ Endovascular treatment Haemorrhagic transformation Outcome Stroke Asymptomatic parenchymal haemorrhage following endovascular treatment : Impact on functional outcome in patients with acute ischaemic stroke Article