2026-04-17T00:59:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4767802025-09-17T07:37:50Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Mehta, Gautam author Riva, Antonio author Ballester, M.P author Uson, Eva author Pujadas, Montserrat author Carvalho Gomes, Ângela author Sahuco, Ivan author Bono, Ariadna author D'Amico, Federico author Viganò, Raffaela author Diago, Elena author Lanseros, Beatriz Tormo author Inglese, Elvira author Vazquez, Dani Martinez author Sharma, Rajni author Tsou, Hio Lam Phoebe author Harris, Nicola author Broekhoven, Annelotte author Kikkert, Marjolein author Torres Morales, Shessy P. author Myeni, Sebenzile K. author Riveiro Barciela, Mar author Palom, Adriana author Zeni, Nicola author Brocca, Alessandra author Cussigh, Annarosa author Cmet, Sara author Escudero-García, Desamparados author Stocco, Matteo author Natola, Leonardo Antonio author Ieluzzi, Donatella author Paon, Veronica author Sangiovanni, Angelo author Farina, Elisa author di Benedetto, Clara author Sánchez-Torrijos, Yolanda María author Lucena-Varela, Ana author Roman, Eva author Sánchez, Elisabet author Sánchez-Aldehuelo, Rubén author López-Cardona, Julia author Canas-Perez, Itzel author Eastgate, Christine author Jeyanesan, Dhaarica author Morocho, Alejandro Esquivel author Di Cola, Simone author Lapenna, Lucia author Zaccherini, Giacomo author Bongiovanni, Deborah author Zanaga, Paola author Sayaf, Katia author Hossain, Sabir author Crespo García, Javier author Robles Díaz, Mercedes author Madejón, Antonio author Degroote, Helena author Fernández, Javier R. author Korenjak, Marko author Verhelst, Xavier author García-Samaniego, Javier author Andrade Bellido, Raúl Jesús author Iruzubieta, Paula author Wright, Gavin author Caraceni, Paolo author Merli, Manuela author Patel, Vishal C. author Gander, Amir author Albillos, Agustín author Soriano, German author Donato, Maria Francesca author Sacerdoti, David author Toniutto, Pierluigi author Buti, Maria author Duvoux, Christophe author Grossi, Paolo Antonio author Berg, Thomas author Polak, Wojciech Grzegorz author Puoti, Massimo author Bosch-Comas, Anna author Belli, Luca Saverio author Burra, Patrizia author Russo, Francesco Paolo author Coenraad, Minneke author Calleja, Jose Luis author Perricone, Giovanni author Berenguer, Marina author Claria, Joan author Moreau, Richard author Arroyo, Vicente author Angeli, Paolo author Sánchez, Cristina author Ampuero, Javier author Piano, Salvatore author Chokshi, Shilpa author Jalan, Rajiv author Universitat Autònoma de Barcelona author 2023 Vaccine hesitancy and lack of access remain major issues in disseminating COVID-19 vaccination to liver patients globally. Factors predicting poor response to vaccination and risk of breakthrough infection are important data to target booster vaccine programs. The primary aim of the current study was to measure humoral responses to 2 doses of COVID-19 vaccine. Secondary aims included the determination of factors predicting breakthrough infection. COVID-19 vaccination and Biomarkers in cirrhosis And post-Liver Transplantation is a prospective, multicenter, observational case-control study. Participants were recruited at 4-10 weeks following first and second vaccine doses in cirrhosis [n = 325; 94% messenger RNA (mRNA) and 6% viral vaccine], autoimmune liver disease (AILD) (n = 120; 77% mRNA and 23% viral vaccine), post-liver transplant (LT) (n = 146; 96% mRNA and 3% viral vaccine), and healthy controls (n = 51; 72% mRNA, 24% viral and 4% heterologous combination). Serological end points were measured, and data regarding breakthrough SARS-CoV-2 infection were collected. After adjusting by age, sex, and time of sample collection, anti-Spike IgG levels were the lowest in post-LT patients compared to cirrhosis (p < 0.0001), AILD (p < 0.0001), and control (p = 0.002). Factors predicting reduced responses included older age, Child-Turcotte-Pugh B/C, and elevated IL-6 in cirrhosis; non-mRNA vaccine in AILD; and coronary artery disease, use of mycophenolate and dysregulated B-call activating factor, and lymphotoxin-α levels in LT. Incident infection occurred in 6.6%, 10.6%, 7.4%, and 15.6% of cirrhosis, AILD, post-LT, and control, respectively. The only independent factor predicting infection in cirrhosis was low albumin level. LT patients present the lowest response to the SARS-CoV-2 vaccine. In cirrhosis, the reduced response is associated with older age, stage of liver disease and systemic inflammation, and breakthrough infection with low albumin level. Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant