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00925njm 22002777a 4500 dc de Lucas, Raúl author Moreno-Arias, Gerardo author Pérez-López, Montserrat author Vera-Casaño, Ángel author Aladren, Sonia author Milani, Massimo author Abellaneda Fernández, Cristina author Aguayo Leyva, Ingrid Rocío author Alcaraz León, Inmaculada author Alonso García, Ignacio author Arechalde Pérez, Ana author Balbín Carrero, Eva author Ballestero Corominas, Alejandro author Bilbao Badiola, Ibon author Boada, Aram author Ciudad Blanco, Cristina author del Pozo Hernando, Luis Javier author Del Rio Reyes, Rosa author Eguino Gorrochategui, Patricia author Escalas Taberner, Juan author Espelt Otero, Jorge Luis author Fernández Angel, Isabel author Fernández Casado, Alex author Fernández Torres, Rosa Ma. author Gallego Álvarez, Silvia author Galvany Rosell, Loida author Gamo-Villegas, Reyes author Ginarte Val, Manuel author Gómez Fernández, Cristina author Gómez Vázquez, Mercedes author Gutiérrez De La Peña, Javier author Hernandez Cano, Natalia author Houmani Houmani, Manmoud author Ibargoyen Esnal, Jesús author Iglesias Sancho, Maribel author Izquierdo Herce, Noelia author Jeremías Torruella, Javier author Latorre Fuentes, Jose Maria author Llambrich Mañes, Alex author López Ferrer, Anna author Mariscal Polo, Amaia author Márquez Balbas, Gemma author Martin Ezquerra, Gemma author Martin Urda, Maria Teresa author Martinez Escala, Maria Estela author Martinez Fernández, Matilde author Mieras Barceló, Caterina author Molina Ruiz, Ana author Montero Pérez, Iria author Nadal Llado, Cristina author Naranjo Díaz, Maria José author Nasarre Calvo, Jaume author Navajas Pinedo, Belén author Oleaga Morante, José Manuel author Perelló Llinas, Guillermo author Pérez Losada, Maria Eugenia author Pérez-Beato De Cos, Maria Paz author Pestoni Porven, Carmela author Poza Magdalena, Olga author Rocamora Duran, Vicenç author Rodriguez Caruncho, Clara author Rodriguez Granados, Maria Teresa author Roé Crespo, Esther author Ruiz Carrascosa, José Carlos author Salgado Boquete, Laura author Sanchez Muros, Virginia author Sanz De Galdeano Palacio, Carmen author Taberner, Rosa author Trasobares Marugan, Lidia author Uria García, Ma Carmen author Valle Martin, Ma del Mar author Valle Santana, Pilar author Vázquez García, Juan author Velasco Pastor, Manuel author Vilarrasa-Rull, Eva author Waadad Waadad, Tamim author Universitat Autònoma de Barcelona. Departament de Medicina author 2015 Background: In acne, several studies report a poor adherence to treatments. We evaluate, in a real-life setting conditions, the impact of compliance to physician's instructions, recommendations and adherence to the treatments on clinical outcome in patients with mild to moderate acne in an observational, non-interventional prospective study carried out in 72 Dermatologic Services in Spain (ACTUO Trial). Methods: Six-hundred-forty-three subjects were enrolled and 566 patients (88 %) completed the 3 study visits. Study aimed to evaluate the impact of adherence (assessed with ECOB scale) on clinical outcome, as well as how the use of specific adjuvant treatments (facial cleansing, emollient, moisturizing and lenitive specific topical products) influences treatment's adherence and acne severity (0-5 points score). Recommendation of specific adjuvant skin barrier repair products was made in 85.2 %. Results: Overall, clinical improvement was observed throughout follow-up visits with an increased proportion of patients who reported reductions of ≥50 % on the total number of lesions (2 months: 25.2 %; 3 months: 57.6 %) and reductions of severity scores (2.5, 2.0 and 1.3 at 1, 2 and 3 months after treatment, respectively). Adherence to treatment was associated with a significant reduction on severity grading, a lower number of lesions and a higher proportion of patients with ≥50 % improvement. Conclusions: Good adherence to medication plus adherence to adjuvants was significantly associated with a higher clinical improvement unlike those that despite adherence with medication had a low adherence to adjuvants. A good adherence to adjuvant treatment was associated with improved adherence and better treatment outcomes in mild to moderate acne patients. (ISRCTN Registry: ISRCTN14257026). Acne vulgaris Emollients Observational study Patient adherence Topical administration Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne : The ACTUO observational prospective multicenter cohort trial in 643 patients