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oai:recercat.cat:2072/4767112025-10-05T12:53:26Zcom_2072_98col_2072_378192

urn:hdl:2072/476711 Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne : The ACTUO observational prospective multicenter cohort trial in 643 patients de Lucas, Raúl Moreno-Arias, Gerardo Pérez-López, Montserrat Vera-Casaño, Ángel Aladren, Sonia Milani, Massimo Abellaneda Fernández, Cristina Aguayo Leyva, Ingrid Rocío Alcaraz León, Inmaculada Alonso García, Ignacio Arechalde Pérez, Ana Balbín Carrero, Eva Ballestero Corominas, Alejandro Bilbao Badiola, Ibon Boada, Aram Ciudad Blanco, Cristina del Pozo Hernando, Luis Javier Del Rio Reyes, Rosa Eguino Gorrochategui, Patricia Escalas Taberner, Juan Espelt Otero, Jorge Luis Fernández Angel, Isabel Fernández Casado, Alex Fernández Torres, Rosa Ma. Gallego Álvarez, Silvia Galvany Rosell, Loida Gamo-Villegas, Reyes Ginarte Val, Manuel Gómez Fernández, Cristina Gómez Vázquez, Mercedes Gutiérrez De La Peña, Javier Hernandez Cano, Natalia Houmani Houmani, Manmoud Ibargoyen Esnal, Jesús Iglesias Sancho, Maribel Izquierdo Herce, Noelia Jeremías Torruella, Javier Latorre Fuentes, Jose Maria Llambrich Mañes, Alex López Ferrer, Anna Mariscal Polo, Amaia Márquez Balbas, Gemma Martin Ezquerra, Gemma Martin Urda, Maria Teresa Martinez Escala, Maria Estela Martinez Fernández, Matilde Mieras Barceló, Caterina Molina Ruiz, Ana Montero Pérez, Iria Nadal Llado, Cristina Naranjo Díaz, Maria José Nasarre Calvo, Jaume Navajas Pinedo, Belén Oleaga Morante, José Manuel Perelló Llinas, Guillermo Pérez Losada, Maria Eugenia Pérez-Beato De Cos, Maria Paz Pestoni Porven, Carmela Poza Magdalena, Olga Rocamora Duran, Vicenç Rodriguez Caruncho, Clara Rodriguez Granados, Maria Teresa Roé Crespo, Esther Ruiz Carrascosa, José Carlos Salgado Boquete, Laura Sanchez Muros, Virginia Sanz De Galdeano Palacio, Carmen Taberner, Rosa Trasobares Marugan, Lidia Uria García, Ma Carmen Valle Martin, Ma del Mar Valle Santana, Pilar Vázquez García, Juan Velasco Pastor, Manuel Vilarrasa-Rull, Eva Waadad Waadad, Tamim Universitat Autònoma de Barcelona. Departament de Medicina Acne vulgaris Emollients Observational study Patient adherence Topical administration Background: In acne, several studies report a poor adherence to treatments. We evaluate, in a real-life setting conditions, the impact of compliance to physician's instructions, recommendations and adherence to the treatments on clinical outcome in patients with mild to moderate acne in an observational, non-interventional prospective study carried out in 72 Dermatologic Services in Spain (ACTUO Trial). Methods: Six-hundred-forty-three subjects were enrolled and 566 patients (88 %) completed the 3 study visits. Study aimed to evaluate the impact of adherence (assessed with ECOB scale) on clinical outcome, as well as how the use of specific adjuvant treatments (facial cleansing, emollient, moisturizing and lenitive specific topical products) influences treatment's adherence and acne severity (0-5 points score). Recommendation of specific adjuvant skin barrier repair products was made in 85.2 %. Results: Overall, clinical improvement was observed throughout follow-up visits with an increased proportion of patients who reported reductions of ≥50 % on the total number of lesions (2 months: 25.2 %; 3 months: 57.6 %) and reductions of severity scores (2.5, 2.0 and 1.3 at 1, 2 and 3 months after treatment, respectively). Adherence to treatment was associated with a significant reduction on severity grading, a lower number of lesions and a higher proportion of patients with ≥50 % improvement. Conclusions: Good adherence to medication plus adherence to adjuvants was significantly associated with a higher clinical improvement unlike those that despite adherence with medication had a low adherence to adjuvants. A good adherence to adjuvant treatment was associated with improved adherence and better treatment outcomes in mild to moderate acne patients. (ISRCTN Registry: ISRCTN14257026). 2015 Article BMC Dermatology ; Vol. 15 Núm. 1 (september 2015), p. 17 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/