2026-04-13T07:34:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4752442025-10-27T12:07:06Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Ge, Ruiyang author Yu, Yuetong author Qi, Yi Xuan author Fan, Yunan Vera author Chen, Shiyu author Gao, Chuntong author Haas, Shalaila S author Modabbernia, Amirhossein author New, Faye author Agartz, Ingrid author Asherson, Philip author Ayesa-Arriola, Rosa author Banaj, Nerisa author Banaschewski, Tobias author Baumeister, Sarah author Bertolino, Alessandro author Boomsma, Dorret I. author Borgwardt, Stefan author Bourque, Josiane author Brandeis, Daniel author Breier, Alan author Brodaty, Henry author Brouwer, Rachel M author Buckner, Randy author Buitelaar, Jan author Cannon, Dara M author Caseras, Xavier author Cervenka, Simon author Conrod, Patricia author Crespo-Facorro, Benedicto author Crivello, Fabrice author Crone, Eveline A author de Haan, Liewe author de Zubicaray, Greig author Di Giorgio, Annabella author Erk, Susanne author Fisher, Simon E author Franke, Barbara author Frodl, Thomas author Glahn, David C. author Grotegerd, Dominik author Gruber, Oliver author Gruner, Patricia author Gur, Raquel E author Gur, Ruben C author Harrison, Ben J author Hatton, Sean N. author Hickie, Ian author Howells, Fleur M. author Pol, Hilleke E Hulshoff author Huyser, Chaim author Jernigan, Terry L author Jiang, Jiyang author Joska, John A author Kahn, René S author Kalnin, Andrew J author Kochan, Nicole A author Koops, Sanne author Kuntsi, Jonna author Lagopoulos, Jim author Lazaro, Luisa author Lebedeva, Irina author Lochner, Christine author Martin, Nicholas G. author Mazoyer, Bernard author McDonald, Brenna C author McDonald, Colm author McMahon, Katie L author Nakao, Tomohiro author Nyberg, Lars author Piras, Fabrizio author Portella Moll, Maria J., 1975- author Qiu, Jiang author Roffman, Joshua L author Sachdev, Perminder S. author Sanford, Nicole author Satterthwaite, Theodore D author Saykin, Andrew J author Schumann, Gunter author Sellgren, Carl M author Sim, Kang author Smoller, Jordan W author Soares, Jair author Sommer, Iris E author Spalletta, Gianfranco author Stein, Dan J author Tamnes, Christian K. author Thomopolous, Sophia I author Tomyshev, Alexander S author Tordesillas-Gutiérrez, Diana author Trollor, Julian author van 't Ent, Dennis author van den Heuvel, Odile A author van Erp, Theo GM author van Haren, Neeltje EM author Vecchio, Daniela author Veltman, Dick J author Walter, Henrik author Wang, Yang author Weber, Bernd author Wei, Dongtao author Wen, Wei author Westlye, Lars T author Wierenga, Lara M author Williams, Steven CR author Wright, Margaret J author Medland, Sarah author Wu, Mon-Ju author Yu, Kevin author Jahanshad, Neda author Thompson, Paul M author Frangou, Sophia author Universitat Autònoma de Barcelona author 2023 We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical age-related neuroanatomical changes and support future study designs. This framework was developed using regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The Multivariate Factorial Polynomial Regression (MFPR) emerged as the preferred algorithm optimized using nonlinear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins, and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3,000 study participants. The model and scripts described here are freely available through CentileBrain (). Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain : Algorithm Benchmarking and Model Optimization