2026-04-17T08:05:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4717662024-11-04T06:49:18Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Farràs Mañé, Marta author Arranz, Sara author Carrión, Silvia author Subirana, Isaac author Muñoz Aguayo, Daniel author Blanchart, Gemma author Kool, Marjon author Solà, Rosa author Motilva, María José author Escolà-Gil, Joan Carles author Rubió, Laura author Fernández-Castillejo, Sara author Pedret, Anna author Estruch, Ramón author Covas Planells, Maria Isabel author Fitó, Montserrat author Hernáez, Álvaro author Castañer, Olga author Universitat Autònoma de Barcelona author 2019 The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0.041 and P = 0.053, versus baseline and the control intervention, respectively), CAV1 (P = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (P = 0.005, P = 0.005, and P = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes. http://hdl.handle.net/2072/471766 HDL cholesterol Cholesterol efflux Functional virgin olive oil Olive oil phenolic compounds Thyme phenolic compounds Transcriptomics A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes : A randomized, crossover, controlled trial