2026-04-14T04:46:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4716582025-08-31T16:43:35Zcom_2072_98col_2072_378192

Clinical presentation of individuals with human T-cell leukemia virus type-1 infection in Spain De Mendoza, Carmen Piron, Maria Gonzalez, Rocío Jiménez, Ana Caballero Requero, Estrella Roc, Lourdes Benito, Rafael Ramos, José Manuel Soriano, Vicente Rodríguez, Carmen Vera, M. Del Romero, Jorge Marcaida, Goitzane Ocete, M.D. Molina Romero, Israel Aguilera, Antonio Rodríguez-Calviño, J.J. Navarro, Daniel Rivero, C. Vilariño, M.D. Algarate, S. Gil, J. Ortiz de Lejarazu, Raúl Rojo, Silvia Eirós, José M. San Miguel, A. Manzardo, Christian Miró, José M. García, Juan Paz, Irmia Poveda, Eva Calderón, Enrique J. Escudero, Domingo Trigo-Daporta, Matilde Diz, Julio García-Campello, Marta Rodríguez-Iglesias, Manuel Antonio Hernández-Betancor, Araceli Pascual Martín, Antonio Manuel Gimeno Gascon, Adelina Gutiérrez, Fernando Rodríguez, J.C. Sánchez, V. Gómez-Hernando, C. Cilla, G. Pérez-Trallero, E. López-Aldeguer, J. Fernández-Pereira, L. Niubó, Jordi Hernández, M. López-Lirola, A.M. Gómez-Sirvent, J.L. Force, Lluís Cifuentes, Carmen Pérez, S. Morano, Luís Enrique Raya, C. González-Praetorius, A. Pérez, J.L. Peñaranda Vera, Maria Hernáez-Crespo, Silvia Montejo Baranda, Jose Miguel Martínez-Sapiña, Ana María Viciana, Isabel Cabezas, Teresa Lozano, Ana Belén Fernández, Juan Manuel R. García-Bermejo, Isabel Gaspar Alonso-Vega, Gabriel García, Raquel Rodriguez Górgolas Hernandez-Mora, Miguel Vegas, César Blas, Jorge Roman Miralles, Pilar Nr. Valeiro, M. Aldámiz-Echevarría, T Margall, Núria Guardià, Cèlia Do Pico, E. Polo, Isabel De La Hoz Aguinaga, Aitziber Ezpeleta, Carmen Sauleda, Silvia Torres, Pilar González, Roser Blanco, Lidia García Suárez, Avelina Rodríguez-Avial, Icíar Pérez-Rivilla, Alfredo Parra, Patricia Fernández, Marcos Sánchez Fernández-Alonso, Mirian Treviño, Ana Celia Requena, Silvia Benítez-Gutiérrez, Laura M. Cuervas-Mons, Valentín Barreiro, Pablo Corral Pazos de Provens, Octavio Gomez-Gallego, Felix Universitat Autònoma de Barcelona Adult T-cell leukemia Epidemiology HTLV-1 Myelopathy Screening Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses. 2019 Article https://ddd.uab.cat/record/285229 urn:10.1093/ofid/ofz036 urn:oai:ddd.uab.cat:285229 urn:scopus_id:85064261083 urn:pmid:30815504 urn:pmc-uid:6386801 urn:pmcid:PMC6386801 urn:oai:pubmedcentral.nih.gov:6386801 eng Open Forum Infectious Diseases ; Vol. 6 Núm. 2 (january 2019) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf