2026-04-17T07:49:43Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4706172024-11-04T06:28:27Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Lorca, Cristina author Laparra, Moisés author Céspedes, María Virtudes author Casaní, Laura author Florit, Sergi author Jové, Mariona author Mota-Martorell, Natàlia author Vilella, Elisabet author Gallart-Palau, Xavier author Serra, Aida author 2022 Altres ajuts: Research and Education Council of the Community of Madrid (2018-T1/BIO-10633); Talento Program 2018, Community of Madrid; European Union Funds; European Social (PEJD-2019-PRE/BIO-16475); CERCA Program, Generalitat de Catalunya. Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. This study explores and defines the use of food industry by-products (BP) as a circular source of safe biocompatible EVs. Averaged diameter and molecular compositions indicate a large yield of exosomes and high abundancy of membrane lipids with signaling capacity in these vesicles. Complex proteomes mimicking those circulating in human blood plasma are also identified. Furthermore, BP-EVs do not show relevant cytotoxicity and display excellent oral and intravenous bioavailability together with specific organ targeting capacity. Collectively, it is believed that the novel findings reported here will open substantial venues for the use of BP as an optimal source of biocompatible nanovesicles in manifold applications of the biotechnological and biomedical fields. http://hdl.handle.net/2072/470617 Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles