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Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy Caravaca-Fontan, Fernando Cavero Escribano, Teresa Díaz Encarnación, Montserrat Mercedes Cabello, Virginia Ariceta Iraola, Gema Quintana, Luis F Marco Rusiñol, Helena Barros, Xoana Ramos Terrades, Natalia Rodríguez-Mendiola, Nuria Cruz, Sonia Fernández-Juárez, Gema Rodríguez, Adela Pérez de José, Ana Rabasco, Cristina Rodado, Raquel Fernández, Loreto Pérez-Gómez, Vanessa Ávila, Ana Bravo, Luis Espinosa, Natalia Allende, Natalia Sanchez de la Nieta, Maria Dolores Rodríguez García, Eva Rivas, Begoña Melgosa, Marta Huerta, Ana Miquel, Rosa Mon, Carmen Fraga Rodríguez, Gloria María De Lorenzo, Alberto Draibe, Juliana González, Fayna Shabaka, Amir López-Rubio, Maria Esperanza Fenollosa, María Ángeles Martín-Penagos, Luis Da Silva, Iara Titos, Juana Alonso Rodríguez de Córdoba, Santiago Goicoechea De Jorge, Elena Praga, Manuel Universitat Autònoma de Barcelona Chronic kidney disease Complement Glomerulonephritis C3 glomerulopathy is a rare kidney disease, which makes it difficult to collect large cohorts of patients to better understand its variability. The aims of this study were to describe the clinical profiles and patterns of progression of kidney disease. This was a retrospective, observational cohort study. Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled. Study population was divided into clinical profiles by combining the following predictors: eGFR under/above 30 ml/min per 1.73 m 2, proteinuria under/above 3.5 g/d, and histologic chronicity score under/above 4. The change in eGFR and proteinuria over time was evaluated in a subgroup with consecutive measurements of eGFR and proteinuria. One hundred and fifteen patients with a median age of 30 years (interquartile range 19-50) were included. Patients were divided into eight clinical profiles. Kidney survival was significantly higher in patients with a chronicity score <4 and proteinuria <3.5 g/d, both in those presenting with an eGFR under/above 30 ml/min per 1.73 m 2. The median eGFR slope of patients who reached kidney failure was -6.5 ml/min per 1.73 m 2 per year (interquartile range -1.6 to -17). Patients who showed a reduction in proteinuria over time did not reach kidney failure. On the basis of the rate of eGFR decline, patients were classified as faster eGFR decline (≥5 ml/min per 1.73 m 2 per year), slower (<5 ml/min per 1.73 m 2 per year), and those without decline. A faster eGFR decline was associated with higher probability of kidney failure. Kidney survival is significantly higher in patients with a chronicity score <4 and proteinuria <3.5 g/d regardless of baseline eGFR, and a faster rate of decline in eGFR is associated with higher probability of kidney failure. 2023 Article Ministerio de Economía y Competitividad PI16/01685 Ministerio de Economía y Competitividad RD12/0021/0029 Agencia Estatal de Investigación PID2019-104912RB-I00 Kidney360 ; Vol. 4 (march 2023), p. 659-672 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/