2026-04-13T13:36:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4695142024-11-04T06:09:46Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Pardo, Mònica author Gregorio, Sara author Montalban, Enrica author Pujadas, Lluís author Elias-Tersa, Alba author Masachs, Nuria author Vílchez-Acosta, Alba author Parent, Annabelle author Auladell, Carme author Girault, Jean-Antoine author Vila Bover, Miquel author Nairn, Angus C. author Manso Sanz, Yasmina author Soriano García, Eduardo author 2023 In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder. Moreover, heterozygous reeler mice exhibit features reminiscent of these disorders, while overexpression of Reelin protects against its manifestation. However, how Reelin influences the structure and circuits of the striatal complex, a key region for the above-mentioned disorders, is far from being understood, especially when altered Reelin expression levels are found at adult stages. In the present study, we took advantage of complementary conditional gain- and loss-of-function mouse models to investigate how Reelin levels may modify adult brain striatal structure and neuronal composition. Using immunohistochemical techniques, we determined that Reelin does not seem to influence the striatal patch and matrix organization (studied by μ-opioid receptor immunohistochemistry) nor the density of medium spiny neurons (MSNs, studied with DARPP-32). We show that overexpression of Reelin leads to increased numbers of striatal parvalbumin- and cholinergic-interneurons, and to a slight increase in tyrosine hydroxylase-positive projections. We conclude that increased Reelin levels might modulate the numbers of striatal interneurons and the density of the nigrostriatal dopaminergic projections, suggesting that these changes may be involved in the protection of Reelin against neuropsychiatric disorders. http://hdl.handle.net/2072/469514 Reelin Striatum Interneurons Dopamine projections Schizophrenia Tourette's syndrome Adult-specific Reelin expression alters striatal neuronal organization : implications for neuropsychiatric disorders