2026-04-17T12:55:53Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4694832025-04-03T09:31:13Zcom_2072_98col_2072_378192
RECERCAT author Burdukiewicz, Michał author Rafacz, Dominik author Barbach, Agnieszka author Hubicka, Katarzyna author Bąkała, Laura author Lassota, Anna author Stecko, Jakub author Szymańska, Natalia author Wojciechowski, Jakub W. author Kozakiewicz, Dominika author Szulc, Natalia author Chilimoniuk, Jaroslaw author Jęśkowiak, Izabela author Gąsior-Głogowska, Marlena author Kotulska, Małgorzata 2022 Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), obtaining details of 883 experimentally studied interactions between 46 amyloid proteins or peptides. We also proposed a novel standardized terminology for the description of amyloid-amyloid interactions, which is included in our database, covering all currently known types of such a cross-talk, including inhibition of fibrillization, cross-seeding and other phenomena. The new approach allows for more specific studies on amyloids and their interactions, by providing very well-defined data. AmyloGraph, an online database presenting information on amyloid-amyloid interactions, is available at (). Its functionalities are also accessible as the R package (). AmyloGraph is the only publicly available repository for experimentally determined amyloid-amyloid interactions. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ AmyloGraph : a comprehensive database of amyloid-amyloid interactions Article