2026-04-14T04:24:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4694832025-04-03T09:31:13Zcom_2072_98col_2072_378192

urn:hdl:2072/469483 AmyloGraph : a comprehensive database of amyloid-amyloid interactions Burdukiewicz, Michał Rafacz, Dominik Barbach, Agnieszka Hubicka, Katarzyna Bąkała, Laura Lassota, Anna Stecko, Jakub Szymańska, Natalia Wojciechowski, Jakub W. Kozakiewicz, Dominika Szulc, Natalia Chilimoniuk, Jaroslaw Jęśkowiak, Izabela Gąsior-Głogowska, Marlena Kotulska, Małgorzata Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), obtaining details of 883 experimentally studied interactions between 46 amyloid proteins or peptides. We also proposed a novel standardized terminology for the description of amyloid-amyloid interactions, which is included in our database, covering all currently known types of such a cross-talk, including inhibition of fibrillization, cross-seeding and other phenomena. The new approach allows for more specific studies on amyloids and their interactions, by providing very well-defined data. AmyloGraph, an online database presenting information on amyloid-amyloid interactions, is available at (). Its functionalities are also accessible as the R package (). AmyloGraph is the only publicly available repository for experimentally determined amyloid-amyloid interactions. 2022 Article Nucleic acids research ; Vol. 51 (october 2022), p. D352-D357 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/