2026-04-17T20:20:31Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4694822024-11-04T06:09:11Zcom_2072_98col_2072_378192
RECERCAT author Vandelli, Andrea author Arnal, Magdalena author Monti, Michele author Fiorentino, Jonathan author Broglia, Laura author Colantoni, Alessio author Sánchez de Groot, Natalia author Torrent Burgas, Marc author Armaos, Alexandros author Tartaglia, Gian Gaetano 2024-11-04T06:09:11Z 2024-11-04T06:09:11Z 2023 http://hdl.handle.net/2072/469482 Biological condensates are membraneless organelles with different material properties. Proteins and RNAs are the main components, but most of their interactions are still unknown. Here, we introduce PRALINE, a database for the interrogation of proteins and RNAs contained in stress granules, processing bodies and other assemblies including droplets and amyloids. PRALINE provides information about the predicted and experimentally validated protein-protein, protein-RNA and RNA-RNA interactions. For proteins, it reports the liquid-liquid phase separation and liquid-solid phase separation propensities. For RNAs, it provides information on predicted secondary structure content. PRALINE shows detailed information on human single-nucleotide variants, their clinical significance and presence in protein and RNA binding sites, and how they can affect condensates' physical properties. PRALINE is freely accessible on the web at . open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ The PRALINE database : protein and Rna humAn singLe nucleotIde variaNts in condEnsates Article