2026-04-13T16:40:53Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4690352025-10-27T10:59:10Zcom_2072_98col_2072_378192
RECERCAT author Delaby, Constance author Teunissen, Charlotte E. author Blennow, Kaj author Alcolea, Daniel author Arisi, Ivan author Amar, Elodie Bouaziz author Beaume, Anne author Bedel, Aurelie author Bellomo, Giovanni author Bigot-Corbel, Edith author Bjerke, Maria author Blanc-Quintin, Marie-Céline author Boada, Mercè author Bousiges, Olivier author Chapman, Miles D author DeMarco, Mari L. author D'Onofrio, Mara author Dumurgier, Julien author Dufour-Rainfray, Diane author Engelborghs, Sebastiaan author Esselmann, Hermann author Fogli, Anne author Gabelle, Audrey author Galloni, Elisabetta author Gondolf, Clémentine author Grandhomme, Frédérique author Grau-Rivera, Oriol author Hart, Melanie author Ikeuchi, Takeshi author Jeromin, Andreas author Kasuga, Kensaku author Keshavan, Ashvini author Khalil, Michael author Körtvelyessy, Peter author Kulczynska-Przybik, Agnieszka author Laplanche, Jean-Louis author Lewczuk, Piotr author Li, Qiao-Xin author Lleó, Alberto author Malaplate, Catherine author Marquié, Marta author Masters, Colin L. author Mroczko, Barbara author Nogueira, Léonor author Orellana, Adelina author Otto, Markus author Oudart, Jean-Baptiste author Paquet, Claire author Paoletti, Federico Paolini author Parnetti, Lucilla author Perret-Liaudet, Armand author Peoc'h, Katell author Poesen, Koen author Puig-Pijoan, Albert author Quadrio, Isabelle author Quillard-Muraine, Muriel author Rucheton, Benoit author Schraen, Susanna author Schott, Jonathan M. author Shaw, Leslie M. author Suárez-Calvet, Marc author Tsolaki, Magda author Tumani, Hayrettin author Udeh-Momoh, Chinedu author Vaudran, Lucie author Verbeek, Marcel M author Verde, Federico author Vermunt, Lisa author Vogelgsang, Jonathan author Wiltfang, Jens author Zetterberg, Henrik author Lehmann, Sylvain author Universitat Autònoma de Barcelona 2021 The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/ Alzheimer's disease Cerebrospinal fluid biomarkers Clinical report Consensus approach Harmonization Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease : An international overview Article