2026-04-13T07:27:50Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4671542026-03-28T08:31:03Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Canyelles, Marina author Borràs, Carla author Rotllan, Noemi author Tondo Colomer, Mireia author Escolà-Gil, Joan Carles author Blanco Vaca, Francisco author Universitat Autònoma de Barcelona author 2023 Altres ajuts: Red de Investigación en "Enfermedades Metabólicas y Cáncer", RED2018-102799-T ; FPU (Formación de Profesorado Universitario), FPU20/07440 Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) and related complications, such as cardiovascular mortality or major adverse cardiovascular events (MACE). Meta-analyses have postulated that high circulating TMAO levels are associated with an increased risk of cardiovascular events and all-cause mortality, but the link between TMAO and CVD remains not fully consistent. The results of prospective studies vary depending on the target population and the outcome studied, and the adjustment for renal function tends to decrease or reverse the significant association between TMAO and the outcome studied, strongly suggesting that the association is substantially mediated by renal function. Importantly, one Mendelian randomization study did not find a significant association between genetically predicted higher TMAO levels and cardiometabolic disease, but another found a positive causal relationship between TMAO levels and systolic blood pressure, which-at least in part-could explain the link with renal function. The mechanisms by which TMAO can increase this risk are not clearly elucidated, but current evidence indicates that TMAO induces cholesterol metabolism alterations, inflammation, endothelial dysfunction, and platelet activation. Overall, there is no fully conclusive evidence that TMAO is a causal factor of ASCVD, and, especially, whether TMAO induces or just is a marker of hypertension and renal dysfunction requires further study. Atherosclerosis TMAO Mortality CVD Renal function Prospective Gut Microbiota-Derived TMAO : A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?