2026-04-17T01:52:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4664502026-03-28T08:24:48Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Tomasa-Irriguible, Teresa Maria author Sabater-Riera, Joan author Pérez-Carrasco, Marcos author Ortiz-Ballujera, Patricia author Díaz Buendia, Yolanda author Navas Pérez, Ana Maria author Betbesé Roig, Antoni Jordi author Rodríguez-López, Miguel author Ibarz, Mercedes author Olmo-Isasmendi, Aitor author Oliva-Zelaya, Iban author Rovira-Anglès, Conxita author Cano Hernández, Silvia author Vendrell-Torra, Ester author Catalan-Ibars, Rosa-María author Miralbés-Torner, Mar author González de Molina, Francisco Javier author Xirgú, Judith author Marcos Neira, Pilar author 2021 Altres ajuts: Blood Purification Therapies Collaboration Group; Catalan Society of Intensive Care Medicine. Augmented renal clearance (ARC) is a phenomenon that can lead to a therapeutic failure of those drugs of renal clearance. The purpose of the study was to ascertain the prevalence of ARC in the critically ill patient, to study the glomerular filtration rate (GFR) throughout the follow-up and analyze the concordance between the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimation formula and measured GFR. Observational, prospective, multicenter study. ARC was defined as a creatinine clearance greater than 130 ml/min/1.73 m. Eighteen hospitals were recruited. GFR measurements carried out twice weekly during a 2-month follow-up period. A total of 561 patients were included. ARC was found to have a non-negligible prevalence of 30%. More even, up to 10.7% already had ARC at intensive care unit (ICU) admission. No specific pattern of GFR was found during the follow-up. Patients in the ARC group were younger 56.5 (53.5-58.5) versus 66 (63.5-68.5) years than in the non-ARC group, p < 0.001. ICU mortality was lower in the ARC group, 6.9% versus 14.5%, p = 0.003. There was no concordance between the estimation of GFR by the CKD-EPI formula and GFR calculated from the 4-h urine. ARC is found in up to 30% of ICU patients, so renal removal drugs could be under dosed by up to 30%. And ARC is already detected on admission in 10%. It is a dynamic phenomenon without an established pattern that usually occurs in younger patients that can last for several weeks. And the CKD-EPI formula does not work to estimate the real creatinine clearance of these patients. Augmented renal clearance ARC Glomerular filtrate rate GFR Chronic Kidney Disease Epidemiology Collaboration formula CKD-EPI Critically ill patient Prevalence Augmented renal clearance. An unnoticed relevant event