2026-04-13T04:03:27Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4664072026-03-28T08:24:07Zcom_2072_98col_2072_378192
RECERCAT author Siddi, Sara author Giné-Vázquez, Iago author Bailón, Raquel author Matcham, Faith author Lamers, Femke author Kontaxis, Spyridon author Laporta, Estela author Garcia, Esther author Arranz, Belén author Dalla Costa, Giancarlo author Guerrero, Ana Isabel author Zabalza, Ana author Buron, Mathias Due author Comi, Giancarlo author Leocani, Letizia author Annas, Peter author Hotopf, Matthew author Penninx, Benda W. J. author Magyari, Melinda author Sørensen, Per S. author Montalban, Xavier author Lavelle, Grance author Ivan, Alina author Oetzmann, Carolin author White, katie M. author Difrancesco, Sonia author Locatelli, Patrick author Mohr, David C. author Aguiló Llobet, Jordi author Narayan, Vaibhav author Folarin, Amoros author Dobson, Richard James Butler author Dineley, Judith author Leightley, Daniel author Cummins, Nicholas author Vairavan, Srinivasan author Ranjan, Yathart author Rashid, Zulqarnain author Rintala, Aki author Girolamo, Giovanni De author Preti, Antonio author Simblett, Sara author Wykes, Til author Myin-Germeys, Inez author Haro Abad, Josep Maria 2022 Changes in lifestyle, finances and work status during COVID-19 lockdownsmay have led to biopsychosocial changes in people with pre-existing vulnerabilities such as MajorDepressive Disorders (MDDs) and Multiple Sclerosis (MS). Methods: Data were collected as a part the RADAR-CNS (Remote Assessment of Disease and Relapse-Central Nervous System) program.We analyzed the following data from long-term participants in a decentralized multinational study:J. Clin. Med. 2022, 11, 7163. https://doi.org/10.3390/jcm11237163 https://www.mdpi.com/journal/jcm J. Clin. Med. 2022, 11, 7163 2 of 20 symptoms of depression, heart rate (HR) during the day and night; social activity; sedentary state,steps and physical activity of varying intensity. Linear mixed-effects regression analyses with repeated measures were fitted to assess the changes among three time periods (pre, during and post-lockdown) across the groups, adjusting for depression severity before the pandemic and gender. Results: Participants with MDDs (N = 255) and MS (N = 214) were included in the analyses. Overall,depressive symptoms remained stable across the three periods in both groups. A lower mean HR and HR variation were observed between pre and during lockdown during the day for MDDs and during the night for MS. HR variation during rest periods also decreased between pre- and post-lockdown in both clinical conditions. We observed a reduction in physical activity for MDDs and MS upon the introduction of lockdowns. The group with MDDs exhibited a net increase in social interaction via social network apps over the three periods. Conclusions: Behavioral responses to the lockdown measured by social activity, physical activity and HR may reflect changes in stress in people with MDDs and MS. Remote technology monitoring might promptly activate an early warning of physical and social alterations in these stressful situations. Future studies must explore how stress does or does not impact depression severity. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ Biopsychosocial Response to the COVID-19 Lockdown in People with Major Depressive Disorder and Multiple Sclerosis Article