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00925njm 22002777a 4500 dc Nogueira, Raul G. author Abdalkader, Mohamad author Qureshi, Muhammad M. author Frankel, Michael R. author Mansour, Ossama Yassin author Yamagami, Hiroshi author Qiu, Zhongming author Farhoudi, Mehdi author Siegler, James E. author Yaghi, Shadi author Raz, Eytan author Sakai, Nobuyuki author Ohara, Nobuyuki author Piotin, Michel author Mechtouff, Laura author Eker, Omer author Chalumeau, Vanessa author Kleinig, Timothy J. author Pop, Raoul author Liu, Jianmin author Winters, Hugh S. author Shang, Xianjin author Rodriguez Vasquez, Alejandro author Blasco, Jordi author Arenillas, Juan F. author Martinez-Galdamez, Mario author Brehm, Alex author Psychogios, Marios-Nikos author Lylyk, Pedro author Haussen, Diogo C. author Al-Bayati, Alhamza R. author Mohammaden, Mahmoud H. author Fonseca, Luísa author Luís Silva, M. author Montalverne, Francisco author Renieri, Leonardo author Mangiafico, Salvatore author Fischer, Urs author Gralla, Jan author Frei, Donald author Chugh, Chandril author Mehta, Brijesh P. author Nagel, Simon author Mohlenbruch, Markus author Ortega-Gutierrez, Santiago author Farooqui, Mudassir author Hassan, Ameer E. author Taylor, Allan author Lapergue, Bertrand author Consoli, Arturo author Campbell, Bruce C.V. author Sharma, Malveeka author Walker, Melanie author Van Horn, Noel author Fiehler, Jens author Nguyen, Huy Thang author Nguyen, Quoc T. author Watanabe, Daisuke author Zhang, Hao author Le, Huynh V. author Nguyen, Viet Q. author Shah, Ruchir author Devlin, Thomas author Khandelwal, Priyank author Linfante, Italo author Izzath, Wazim author Lavados, Pablo M. author Olavarría, Veronica V. author Sampaio Silva, Gisele author de Carvalho Sousa, Anna Verena author Kirmani, Jawad author Bendszus, Martin author Amano, Tatsuo author Yamamoto, Ryoo author Doijiri, Ryosuke author Tokuda, Naoki author Yamada, Takehiro author Terasaki, Tadashi author Yazawa, Yukako author Morris, Jane G. author Griffin, Emma author Thornton, John author Lavoie, Pascale author Matouk, Charles author Hill, M. D. author Demchuk, Andrew author Killer-Oberpfalzer, Monika author Nahab, Fadi author Altschul, Dorothea author Ramos-Pachón, Anna author Pérez de la Ossa, Natalia author Kikano, Raghid author Boisseau, William author Walker, Gregory author Cordina, Steve M. author Puri, Ajit author Luisa Kuhn, Anna author Gandhi, Dheeraj author Ramakrishnan, Pankajavalli author Novakovic-White, Roberta author Chebl, Alex author Kargiotis, Odysseas author Czap, Alexandra L. author Zha, Alicia M. author Masoud, Hesham E. author Lopez, Carlos author Ozretic, David author Al-Mufti, Fawaz author Zie, Wenjie author Duan, Zhenhui author Yuan, Zhengzhou author Huang, Wenguo author Hao, Yonggang author Luo, Jun author Kalousek, Vladimir author Bourcier, Romain author Guile, Romain author Hetts, Steven author Al-Jehani, Hosam M. author AlHazzani, Adel author Sadeghi-Hokmabadi, Elyar author Teleb, Mohamed author Payne, Jeremy author Lee, Jin Soo author Hong, Ji Man author Sohn, Sung-Il author Hwang, Yang-Ha author Shin, Dong Hoon author Roh, Hong Gee author Edgell, Randy author Khatri, Rakesh author Smith, Ainsley author Malik, Amer author Liebeskind, David author Herial, Nabeel author Jabbour, Pascal author Magalhaes, Pedro author Ozdemir, Atilla Ozcan author Aykac, Ozlem author Uwatoko, Takeshi author Dembo, Tomohisa author Shimizu, Hisao author Sugiura, Yuri author Miyashita, Fumio author Fukuda, Hiroki author Miyake, Kosuke author Shimbo, Junsuke author Sugimura, Yusuke author Beer-Furlan, Andre author Joshi, Krishna author Catanese, Luciana author Abud, Daniel Giansante author Neto, Octavio Giansante author Mehrpour, Masoud author Al Hashmi, Amal author Saqqur, Mahar author Mostafa, Abdulrahman author Fifi, Johanna T. author Hussain, Syed author John, Seby author Gupta, Rishi author Sivan-Hoffmann, Rotem author Reznik, Anna author Sani, Achmad Fidaus author Geyik, Serdar author Akıl, Eşref author Churojana, Anchalee author Ghoreishi, Abdoreza author Saadatnia, Mohammad author Sharifipour, Ehsan author Ma, Alice author Faulder, Ken author Wu, Teddy author Leung, Lester author Malek, Adel author Voetsch, Barbara author Wakhloo, Ajay author Rivera, Rodrigo author Barrientos Iman, Danny Moises author Pikula, Aleksandra author Lioutas, Vasileios-Arsenios author Thomalla, Gotz author Birnbaum, Lee author Machi, Paolo author Bernava, Gianmarco author McDermott, Mollie author Kleindorfer, Dawn author Wong, Ken author Patterson, Mary S. author Fiorot, Jose Antonio author Huded, Vikram author Mack, William author Tenser, Matthew author Eskey, Clifford author Multani, Sumeet author Kelly, Michael author Janardhan, Vallabh author Cornett, Oriana author Singh, Varsha author Murayama, Yuichi author Mokin, Maxim author Yang, Pengfei author Zhang, Xiaoxi author Yin, Congguo author Han, Hongxing author Peng, Ya author Chen, Wenhuo author Crosa, Roberto author Frudit, Michel E. author Pandian, Jeyaraj D. author Kulkarni, Anirudh author Yagita, Yoshiki author Takenobu, Yohei author Matsumaru, Yuji author Yamada, Satoshi author Kono, Ryuhei author Kanamaru, Takuya author Yamazaki, Hidekazu author Sakaguchi, Manabu author Todo, Kenichi author Yamamoto, Nobuaki author Sonoda, Kazutaka author Yoshida, Tomoko author Hashimoto, Hiroyuki author Nakahara, Ichiro author Cora, Elena author Volders, David author Ducroux, Celina author Shoamanesh, Ashkan author Ospel, Johanna author Kaliaev, Artem author Ahmed, Saima author Rashid, Umair author Rebello, Leticia C. author Pereira, Vitor Mendes author Fahed, Robert author Chen, Michael author Sheth, Sunil A. author Palaiodimou, Lina author Tsivgoulis, Georgios author Chandra, Ronil author Koyfman, Feliks author Leung, Thomas author Khosravani, Houman author Dharmadhikari, Sushrut author Frisullo, Giovanni author Calabresi, Paolo author Tsiskaridze, Alexander author Lobjanidze, Nino author Grigoryan, Mikayel author Czlonkowska, Anna author de Sousa, Diana A. author Demeestere, Jelle author Liang, Conrad author Sangha, Navdeep author Lutsep, Helmi L. author Ayo-Martín, Óscar author Cruz Culebras, Antonio author Tran, Anh D. author Young, Chang Y. author Cordonnier, Charlotte author Caparros, Francois author De Lecinana, Maria Alonso author Fuentes, Blanca author Yavagal, Dileep author Jovin, Tudor author Spelle, Laurent author Moret, Jacques author Khatri, Pooja author Zaidat, Osama author Raymond, Jean author Martins, Sheila author Nguyen, Thanh N. author Universitat Autònoma de Barcelona author 2021 Background: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March-31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, -19.7 to -18.7), 11.5% (95%CI, -12.6 to -10.6), and 12.7% (95%CI, -13.6 to -11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (-20.5%) had greater declines in mechanical thrombectomy volumes than mid- (-10.1%) and low-volume (-8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes. COVID-19 Acute ischemic stroke Epidemiology Intracranial hemorrhage Mechanical thrombectomy Stroke care Global impact of COVID-19 on stroke care