2026-04-17T21:27:25Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4660462026-03-28T08:20:32Zcom_2072_98col_2072_378192

Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese Canyelles, Marina Pérez Pérez, Antonio Junza, Alexandra Miñambres, Inka Yanes, Oscar Sardà, Helena Rotllan, Noemi Julve i Gil, Josep Sánchez Quesada, José Luis Tondo Colomer, Mireia Escolà-Gil, Joan Carles Blanco Vaca, Francisco SDG 3 - Good Health and Well-being High circulating concentrations of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are significantly associated with the risk of obesity and type 2 diabetes (T2D). We aimed at evaluating the impact of glycemic control and bariatric surgery on circulating concentrations of TMAO and its microbiota-dependent intermediate, γ-butyrobetaine (γBB), in newly diagnosed T2D patients and morbidly obese subjects following a within-subject design. Based on HbA1c concentrations, T2D patients achieved glycemic control. However, the plasma TMAO and γBB concentrations were significantly increased, without changes in estimated glomerular filtration rate. Bariatric surgery was very effective in reducing weight in obese subjects. Nevertheless, the surgery reduced plasma γBB concentrations without affecting TMAO concentrations and the estimated glomerular filtration rate. Considering these results, an additional experiment was carried out in male C57BL/6J mice fed a Western-type diet for twelve weeks. Neither diet-induced obesity nor insulin resistance were associated with circulating TMAO and γBB concentrations in these genetically defined mice strains. Our findings do not support that glycemic control or bariatric surgery improve the circulating concentrations of TMAO in newly diagnosed T2D and morbidly obese patients. 2022 Article https://ddd.uab.cat/record/271458 urn:10.3390/diagnostics12112783 urn:oai:ddd.uab.cat:271458 urn:articleid:20754418v12n11ediagnostics12112783 urn:oai:egreta.uab.cat:publications/03e8f08c-0d11-40ec-a062-8e7f8493a807 urn:pure_id:250381165 urn:pmid:36428843 urn:pmc-uid:9689652 urn:pmcid:PMC9689652 urn:oai:pubmedcentral.nih.gov:9689652 urn:scopus_id:85149479019 eng Instituto de Salud Carlos III PI18-00164 Instituto de Salud Carlos III PI21-00140 Instituto de Salud Carlos III PI19-00136 Instituto de Salud Carlos III PI17-00232 Ministerio de Economía y Competitividad PI16-00471 Ministerio de Ciencia e Innovación PID2019-104367RB-100 Instituto de Salud Carlos III CM20/00033 Agencia Estatal de Investigación RYC-201722879 Instituto de Salud Carlos III CPII18/00004 Agencia Estatal de Investigación RED2018-102799-T Diagnostics ; Vol. 12 Núm. 11 (2022) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ application/pdf