2026-04-17T11:59:20Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4656692024-11-04T05:05:01Zcom_2072_98col_2072_378192

The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer Ramesh-Kumar, Deepthi Guil, Sonia IGF2BP proteins M6A-RNA Epitranscriptomics Noncoding RNA Cancer RNA binding proteins that act at the post-transcriptional level display a richness of mechanisms to modulate the transcriptional output and respond to changing cellular conditions. The family of IGF2BP proteins recognize mRNAs modified by methylation and lengthen their lifecycle in the context of stable ribonucleoprotein particles to promote cancer progression. They are emerging as key 'reader' proteins in the epitranscriptomic field, driving the fate of bound substrates under physiological and disease conditions. Recent developments in the field include the recognition that noncoding substrates play crucial roles in mediating the pro-growth features of IGF2BP family, not only as regulated targets, but also as modulators of IGF2BP function themselves. In this review, we summarize the regulatory roles of IGF2BP proteins and link their molecular role as mA modification readers to the cellular phenotype, thus providing a comprehensive insight into IGF2BP function. 2024-11-04T05:05:01Z 2024-11-04T05:05:01Z 2024-11-04T05:05:01Z 2022 Article http://hdl.handle.net/2072/465669 Agencia Estatal de Investigación PID2019-111658RB-100 Seminars in Cancer Biology ; Vol. 86 (november 2022), p. 18-31 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/