2026-04-17T08:08:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4656692024-11-04T05:05:01Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Ramesh-Kumar, Deepthi author Guil, Sonia author 2022 RNA binding proteins that act at the post-transcriptional level display a richness of mechanisms to modulate the transcriptional output and respond to changing cellular conditions. The family of IGF2BP proteins recognize mRNAs modified by methylation and lengthen their lifecycle in the context of stable ribonucleoprotein particles to promote cancer progression. They are emerging as key 'reader' proteins in the epitranscriptomic field, driving the fate of bound substrates under physiological and disease conditions. Recent developments in the field include the recognition that noncoding substrates play crucial roles in mediating the pro-growth features of IGF2BP family, not only as regulated targets, but also as modulators of IGF2BP function themselves. In this review, we summarize the regulatory roles of IGF2BP proteins and link their molecular role as mA modification readers to the cellular phenotype, thus providing a comprehensive insight into IGF2BP function. http://hdl.handle.net/2072/465669 IGF2BP proteins M6A-RNA Epitranscriptomics Noncoding RNA Cancer The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer