2026-04-17T22:52:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4655062025-08-31T15:58:27Zcom_2072_98col_2072_378192

urn:hdl:2072/465506 Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC Ji, Xinyu Lin, Lijuan Fan, Juanjuan Li, Yi Wei, Yongyue Shen, Sipeng Su, Li Shafer, Andrea Bjaanæs, Maria Moksnes Karlsson, Anna Planck, Maria Staaf, Johan Helland, Åslaug Esteller, M Zhang, Ruyang Chen, Feng Christiani, David C Universitat Autònoma de Barcelona Carcinoma, Non-Small-Cell Lung CpG Islands DNA Methylation DNA-Binding Proteins Epigenesis, Genetic Epigenome Genome-Wide Association Study Humans Lung Neoplasms Nuclear Proteins Smoking The interaction between DNA methylation of tripartite motif containing 27 (cg05293407) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small-cell lung cancer (NSCLC) survival. However, to understand the complex mechanisms underlying NSCLC progression, we searched three-way interactions. A two-phase study was adopted to identify three-way interactions in the form of pack-year of smoking (number of cigarettes smoked per day × number of years smoked) × cg05293407 × epigenome-wide DNA methylation CpG probe. Two CpG probes were identified with FDR-q ≤ 0.05 in the discovery phase and P ≤ 0.05 in the validation phase: cg00060500 and cg17479956. Compared to a prediction model with only clinical information, the model added 42 significant three-way interactions using a looser criterion (discovery: FDR-q ≤ 0.10, validation: P ≤ 0.05) had substantially improved the area under the receiver operating characteristic curve (AUC) of the prognostic prediction model for both 3-year and 5-year survival. Our research identified the complex interaction effects among multiple environment and epigenetic factors, and provided therapeutic target for NSCLC patients. 2022 Article Molecular oncology ; Vol. 16 Núm. 3 (february 2022), p. 717-731 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/