2026-04-13T07:31:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4653522026-03-28T08:13:47Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc González-Blanco, Leticia author García-Portilla, María Paz author Gutiérrez, Miguel author Mezquida, Gisela author Cuesta, Manuel J. author Urbiola, Elena author Amoretti, Silvia author Barcones, Fe author González-Pinto, Ana author Pina-Camacho, Laura author Corripio, Iluminada author Vieta, Eduard author Baeza, Inmaculada author Toll, Alba author Sáiz, Pilar A. author Bobes, Julio author Bernardo, Miquel author Bioque, Miquel author Sagué, M. author Alonso-Solís, Anna author Grasa, Eva author González-Ortega, Itxaso author Zorrilla, Iñaki author Santabárbara, Javier author De-la-Cámara, Concepción author Aguilar Cortes, Eduardo author Nacher, Juan author Bergé Baquero, Daniel author Mané, Anna author Montejo, Laura author Anmella, Gerard author Castro-Fornieles, Josefina author de la Serna, Elena author Contreras, Fernando author Sáiz-Masvidal, Cristrina author García-Álvarez, Leticia author Bobes-Bascarán, Maria T. author Zabala Rabadán, Arantzazu author Segarra-Echevarría, Rafael author Sánchez Pastor, Luis author Rodriguez-Jimenez, Roberto author Usall, Judith author Butjosa Molines, Anna author Sarró, Salvador author Guerrero-Pedraza, Amalia author Ibáñez, Ángela author Ribeiro, Maria author Balanzá-Martínez, Vicent author Universitat Autònoma de Barcelona author 2021 Altres ajuts: Ministerio de Economía y Competitividad; Fondo Europeo de Desarrollo Regional (FEDER "A Way of Shaping Europe"); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM). Objective: There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to psychosis onset. The purpose of the study was to determine the impact of previous tobacco use with or without cannabis on first psychotic experiences in FEP and the impact of this use on age of onset of symptoms, including prodromes. Methods: Retrospective analyses from the naturalistic, longitudinal, multicentre, "Phenotype-Genotype and Environmental Interaction. Application of a Predictive Model in First Psychotic Episodes (PEPs)" Study. The authors analysed sociodemographic/clinical data of 284 FEP patients and 231 matched healthy controls, and evaluated first psychotic experiences of patients using the Symptom Onset in Schizophrenia Inventory. Results: FEP patients had significantly higher prevalence of tobacco, cannabis, and cocaine use than controls. The FEP group with tobacco use only prior to onset (N = 56) had more sleep disturbances (42.9% vs 18.8%, P = 0.003) and lower prevalence of negative symptoms, specifically social withdrawal (33.9% vs 58%, P = 0.007) than FEP with no substance use (N = 70), as well as lower prevalence of ideas of reference (80.4% vs 92.4%, P = 0.015), perceptual abnormalities (46.4% vs 67.4%, P = 0.006), hallucinations (55.4% vs 71.5%, P = 0.029), and disorganised thinking (41.1% vs 61.1%, P = 0.010) than FEP group with previous tobacco and cannabis use (N = 144). FEP patients with cannabis and tobacco use had lower age at first prodromal or psychotic symptom (mean = 23.73 years [SD = 5.09]) versus those with tobacco use only (mean = 26.21 [SD = 4.80]) (P = 0.011). Conclusions: The use of tobacco alone was not related to earlier age of onset of a first psychotic experience, but the clinical profile of FEP patients is different depending on previous tobacco use with or without cannabis. Prodromal symptoms First psychotic symptoms Substance use Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis