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oai:recercat.cat:2072/4653522026-03-28T08:13:47Zcom_2072_98col_2072_378192

urn:hdl:2072/465352 Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis González-Blanco, Leticia García-Portilla, María Paz Gutiérrez, Miguel Mezquida, Gisela Cuesta, Manuel J. Urbiola, Elena Amoretti, Silvia Barcones, Fe González-Pinto, Ana Pina-Camacho, Laura Corripio, Iluminada Vieta, Eduard Baeza, Inmaculada Toll, Alba Sáiz, Pilar A. Bobes, Julio Bernardo, Miquel Bioque, Miquel Sagué, M. Alonso-Solís, Anna Grasa, Eva González-Ortega, Itxaso Zorrilla, Iñaki Santabárbara, Javier De-la-Cámara, Concepción Aguilar Cortes, Eduardo Nacher, Juan Bergé Baquero, Daniel Mané, Anna Montejo, Laura Anmella, Gerard Castro-Fornieles, Josefina de la Serna, Elena Contreras, Fernando Sáiz-Masvidal, Cristrina García-Álvarez, Leticia Bobes-Bascarán, Maria T. Zabala Rabadán, Arantzazu Segarra-Echevarría, Rafael Sánchez Pastor, Luis Rodriguez-Jimenez, Roberto Usall, Judith Butjosa Molines, Anna Sarró, Salvador Guerrero-Pedraza, Amalia Ibáñez, Ángela Ribeiro, Maria Balanzá-Martínez, Vicent Universitat Autònoma de Barcelona Prodromal symptoms First psychotic symptoms Substance use Altres ajuts: Ministerio de Economía y Competitividad; Fondo Europeo de Desarrollo Regional (FEDER "A Way of Shaping Europe"); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM). Objective: There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to psychosis onset. The purpose of the study was to determine the impact of previous tobacco use with or without cannabis on first psychotic experiences in FEP and the impact of this use on age of onset of symptoms, including prodromes. Methods: Retrospective analyses from the naturalistic, longitudinal, multicentre, "Phenotype-Genotype and Environmental Interaction. Application of a Predictive Model in First Psychotic Episodes (PEPs)" Study. The authors analysed sociodemographic/clinical data of 284 FEP patients and 231 matched healthy controls, and evaluated first psychotic experiences of patients using the Symptom Onset in Schizophrenia Inventory. Results: FEP patients had significantly higher prevalence of tobacco, cannabis, and cocaine use than controls. The FEP group with tobacco use only prior to onset (N = 56) had more sleep disturbances (42.9% vs 18.8%, P = 0.003) and lower prevalence of negative symptoms, specifically social withdrawal (33.9% vs 58%, P = 0.007) than FEP with no substance use (N = 70), as well as lower prevalence of ideas of reference (80.4% vs 92.4%, P = 0.015), perceptual abnormalities (46.4% vs 67.4%, P = 0.006), hallucinations (55.4% vs 71.5%, P = 0.029), and disorganised thinking (41.1% vs 61.1%, P = 0.010) than FEP group with previous tobacco and cannabis use (N = 144). FEP patients with cannabis and tobacco use had lower age at first prodromal or psychotic symptom (mean = 23.73 years [SD = 5.09]) versus those with tobacco use only (mean = 26.21 [SD = 4.80]) (P = 0.011). Conclusions: The use of tobacco alone was not related to earlier age of onset of a first psychotic experience, but the clinical profile of FEP patients is different depending on previous tobacco use with or without cannabis. 2021 Article Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612 Schizophrenia research ; Vol. 236 (october 2021), p. 19-28 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/