2026-04-13T02:55:18Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4647852026-03-13T10:36:08Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Lv, Feng-Hua author Cao, Yin-Hong author Liu, Guang-Jian author Luo, Ling-Yun author Lu, Ran author Liu, Ming-Jun author Li, Wen-Rong author Zhou, Ping author Wang, Xin-Hua author Shen, Min author Gao, Lei author Yang, Jing-Quan author Yang, Hua author Yang, Yong-Lin author Liu, Chang-Bin author Wan, Peng-Cheng author Zhang, Yun-Sheng author Pi, Wen-Hui author Ren, Yan-Ling author Shen, Zhi-Qiang author Wang, Feng author Wang, Yu-Tao author Li, Jin-Quan author Salehian-Dehkordi, Hosein author Hehua, Eer author Liu, Yong-Gang author Chen, Jian-Fei author Wang, Jian-Kui author Deng, Xue-Mei author Esmailizadeh, Ali author Dehghani-Qanatqestani, Mostafa author Charati, Hadi author Nosrati, Maryam author Štěpánek, Ondřej author Rushdi, Hossam E. author Olsaker, Ingrid author Curik, Ino author Gorkhali, Neena A. author Paiva, Samuel R. author Caetano, Alexandre R. author Ciani, Elena author Amills i Eras, Marcel author Weimann, Christina author Erhardt, Georg author Amane, Agraw author Mwacharo, Joram M. author Han, Jian-Lin author Hanotte, Olivier author Periasamy, Kathiravan author Johansson, Anna M. author Hallsson, Jón H. author Kantanen, Juha author Coltman, David W. author Bruford, Michael W. author Lenstra, Johannes A. author Li, Meng-Hua author 2021 Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3'-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep. Whole-genome sequences Genetic diversity Adaptive introgression Genetic selection Agronomic traits Migration Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci