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oai:recercat.cat:2072/4646112026-03-13T10:34:43Zcom_2072_98col_2072_378192

Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient Wheatley, Rachel M. Caballero, Julio Diaz van der Schalk, Thomas E. De Winter, Fien H. R. Shaw, Liam P. Kapel, Natalia Recanatini, Claudia Timbermont, Leen Kluytmans, Jan Esser, Mark Lacoma, Alicia Prat i Aymerich, Cristina Oliver, Antonio Kumar-Singh, Samir Malhotra-Kumar, Surbhi Craig MacLean, R. Antimicrobials Infection Evolution Antimicrobial resistance Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. Crucially, we show that lung colonization in the ICU was driven by the translocation of P. aeruginosa from the gut. Meropenem treatment for a suspected urinary tract infection selected for elevated resistance in both the gut and lung. However, resistance was driven by parallel evolution in the gut and lung coupled with organ specific selective pressures, and translocation had only a minor impact on AMR. These findings suggest that reducing intestinal colonization of Pseudomonas may be an effective way to prevent lung infections in critically ill patients. 2022 Article https://ddd.uab.cat/record/269166 urn:10.1038/s41467-022-34101-2 urn:oai:ddd.uab.cat:269166 urn:articleid:20411723v13as41467-022-34101-2 urn:pmcid:PMC9681761 urn:pmc-uid:9681761 urn:pmid:36414617 urn:oai:pubmedcentral.nih.gov:9681761 urn:oai:egreta.uab.cat:publications/5dfe1b03-f4bb-4797-8a9c-4357519b0d88 eng European Commission 115737 European Commission 115523 Nature communications ; Vol. 13 (november 2022) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ application/pdf