2026-04-14T03:05:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4646112026-03-13T10:34:43Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Wheatley, Rachel M. author Caballero, Julio Diaz author van der Schalk, Thomas E. author De Winter, Fien H. R. author Shaw, Liam P. author Kapel, Natalia author Recanatini, Claudia author Timbermont, Leen author Kluytmans, Jan author Esser, Mark author Lacoma, Alicia author Prat i Aymerich, Cristina author Oliver, Antonio author Kumar-Singh, Samir author Malhotra-Kumar, Surbhi author Craig MacLean, R. author 2022 Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. Crucially, we show that lung colonization in the ICU was driven by the translocation of P. aeruginosa from the gut. Meropenem treatment for a suspected urinary tract infection selected for elevated resistance in both the gut and lung. However, resistance was driven by parallel evolution in the gut and lung coupled with organ specific selective pressures, and translocation had only a minor impact on AMR. These findings suggest that reducing intestinal colonization of Pseudomonas may be an effective way to prevent lung infections in critically ill patients. Antimicrobials Infection Evolution Antimicrobial resistance Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient