2026-04-17T20:15:12Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4644302026-03-13T10:33:22Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Cruz, Raquel author Diz-de Almeida, Silvia author López de Heredia, Miguel author Quintela, Inés author Ceballos, Francisco C. author Pita, Guillermo author Lorenzo-Salazar, José M. author González-Montelongo, Rafaela author Gago-Dominguez, Manuela author Sevilla Porras, Marta author Tenorio Castaño, Jair Antonio author Nevado, Julián author Aguado, José María author Aguilar Franco, Carlos author Aguilera-Albesa, Sergio author Almadana, Virginia author Almoguera, Berta author Alvarez, Nuria author Andreu-Bernabeu, Álvaro author Arana-Arri, Eunate author Arango, Celso author Arranz, María Jesús author Artiga, Maria-Jesus author Baptista-Rosas, Raúl C. author Barreda-Sánchez, María author Belhassen-Garcia, Moncef author Bezerra, Joao F. author Bezerra, Marcos A C. author Boix-Palop, Lucía author Brion, María author Brugada, Ramon author Bustos, Matilde author Calderón, Enrique J. author Carbonell Abella, Cristina author Castaño, Luis author Castelao, Jose E. author Conde-Vicente, Rosa author Cordero-Lorenzana, M Lourdes author Cortes-Sanchez, Jose L. author Corton, Marta author Darnaude, M Teresa author De Martino-Rodríguez, Alba author Campo Pérez, Víctor del author Diaz de Bustamante, Aranzazu author Domínguez-Garrido, Elena author Luchessi, Andre D. author Eiros, Rocío author Estigarribia Sanabria, Gladys Mercedes author Carmen Fariñas, María author Fernández-Robelo, Uxía author Fernández-Rodríguez, Amanda author Fernández-Villa, Tania author Gil-Fournier, Belén author Gómez-Arrue, Javier author González Álvarez, Beatriz author Gonzalez Bernaldo de Quirós, Fernan author González-Peñas, Javier author Gutiérrez-Bautista, Juan F. author Herrero, María José author Herrero-Gonzalez, Antonio author Jimenez-Sousa, María A. author Lattig, María Claudia author Liger Borja, Anabel author Lopez-Rodriguez, Rosario author Mancebo, Esther author Martín-López, Caridad author Martín, Vicente author Martinez-Nieto, Oscar author Martinez-Lopez, Iciar author Martinez-Resendez, Michel F. author Martinez-Perez, Angel author Mazzeu, Juliana F. author Merayo Macías, Eleuterio author Minguez, Pablo author Moreno Cuerda, Victor author Silbiger, Vivian N. author Oliveira, Silviene F. author Ortega-Paino, Eva author Parellada, Mara author Paz-Artal, Estela author Santos, Ney P C. author Pérez-Matute, Patricia author Perez, Patricia author Pérez-Tomás, M. Elena author Perucho, Teresa author Pinsach-Abuin, Mel Lina author Pompa-Mera, Ericka N. author Porras-Hurtado, Gloria L. author Pujol, Aurora author Ramiro-León, Soraya author Resino, Salvador author Fernandes, Marianne R. author Rodríguez-Ruiz, Emilio author Rodriguez-Artalejo, Fernando author Rodriguez-Garcia, José A. author Ruiz Cabello, Francisco author Ruiz-Hornillos, Javier author Ryan, Pablo author Soria Fernández, José Manuel author Souto, Juan Carlos author Tamayo, Eduardo author Tamayo-Velasco, Alvaro author Taracido-Fernandez, Juan Carlos author Teper, Alejandro author Torres-Tobar, Lilian author Urioste, Miguel author Valencia-Ramos, Juan author Yáñez, Zuleima author Zarate, Ruth N. author Nakanishi, Tomoko author Pigazzini, Sara author Degenhardt, Frauke author Butler-Laporte, Guillaume author Maya-Miles, Douglas author Bujanda, Luis author Bouysran, Youssef author Palom, Adriana author Ellinghaus, David author Martínez-Bueno, Manuel author Rolker, Selina author Amitrano, Sara author Roade, Luisa author Fava, Francesca author Spinner, Christoph D. author Prati, Daniele author Bernardo, D. author Garcia, Federico author Darcis, Gilles author Fernández Cadenas, Israel author Holter, Jan Cato author Banales, Jesus author Frithiof, Robert author Duga, Stefano author Asselta, Rosanna author Pereira, Alexandre C. author Romero-Gómez, Manuel author Nafria-Jimenez, Beatriz author Hov, Johannes R. author Migeotte, Isabelle author Renieri, Alessandra author Planas, Anna Maria author Ludwig, Kerstin U. author Buti, Maria author Rahmouni, Souad author Alarcón-Riquelme, Marta E. author Schulte, Eva C. author Franke, Andre author Karlsen, Tom H. author Valenti, Luca author Zeberg, Hugo author Richards, Brent author Ganna, Andrea author Boada, Mercè author De Rojas, Itziar author Ruiz Laza, Agustín author Sánchez-Juan, Pascual author Real, Luis M. author Guillen-Navarro, Encarna author Ayuso, Carmen author González-Neira, Anna author Riancho, José A. author Rojas-Martinez, Augusto author Flores, Carlos author Lapunzina, Pablo author Carracedo, Ángel author 2022 Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10 -8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10 -22 and P = 8.1 × 10 -12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10 -8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10 -8) and ARHGAP33 (P = 1.3 × 10 -8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10 -8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided. Novel genes and sex differences in COVID-19 severity