2026-04-14T06:18:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4643942026-03-13T10:32:58Zcom_2072_98col_2072_378192

urn:hdl:2072/464394 The Thalamus and its subnuclei-a gateway to obsessive-compulsive disorder Weeland, Cees J. Kasprzak, Selina de Joode, Niels T. Abe, Yoshinari Alonso, Pino Ameis, Stephanie H. Anticevic, Alan Arnold, Paul D. Balachander, Srinivas Banaj, Nerisa Bargalló, Núria Batistuzzo, Marcelo C. Benedetti, Francesco Beucke, Jan C. Bollettini, Irene Brecke, Vilde Brem, Silvia Cappi, Carolina Cheng, Yuqi Cho, Kang Ik K. Costa, Daniel L. C. Dallaspezia, Sara Denys, Damiaan Eng, Goi Khia Ferreira, Sónia Feusner, Jamie D. Fontaine, Martine Fouche, Jean-Paul Grazioplene, Rachael G. Gruner, Patricia He, Mengxin Hirano, Yoshiyuki Hoexter, Marcelo Q. Huyser, Chaim Hu, Hao Jaspers-Fayer, Fern Kathmann, Norbert Kaufmann, Christian Kim, Minah Koch, Kathrin Bin Kwak, Yoo Kwon, Jun Soo Lázaro, Luisa Li, Chiang-shan R. Lochner, Christine Marsh, Rachel Martínez-Zalacaín, Ignacio Mataix-Cols, David Menchón Magriñá, José Manuel Minnuzi, Luciano Moreira, Pedro Silva Morgado, Pedro Nakagawa, Akiko Nakamae, Takashi Narayanaswamy, Janardhanan C. Nurmi, Erika L. Ortiz, Ana E. Pariente, Jose C. Piacentini, John Picó-Pérez, Maria Piras, Fabrizio Piras, Federica Pittenger, Christopher Reddy, Y. C. Janardhan Rodriguez-Manrique, Daniela Sakai, Yuki Shimizu, Eiji Shivakumar, Venkataram Simpson, Helen Blair Soreni, Noam Soriano-Mas, Carles Sousa, N. Spalletta, Gianfranco Stern, Emily R. Stevens, Michael C. Stewart, S. Evelyn Szeszko, Philip R. Takahashi, Jumpei Tanamatis, Tais Tang, Jinsong Thorsen, Anders Lillevik Tolin, David van der Werf, Ysbrand D. van Marle, Hein van Wingen, Guido Vecchio, Daniela Venkatasubramanian, Ganesan Walitza, Susanne Wang, Jicai Wang, Zhen Watanabe, Anri Wolters, Lidewij H. Xu, Xiufeng Yun, Je-Yeon Zhao, Qing White, Tonya Thompson, Paul M. Stein, Dan J. van den Heuvel, Odile A. Vriend, Chris Psychiatric disorders Neuroscience Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered () and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p -values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = - 0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status. 2022 Article Translational psychiatry ; Vol. 12 (february 2022) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/