2026-04-17T00:48:11Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4635822025-02-25T17:08:44Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Pleguezuelos, Patricia author Sibila, Marina author Cuadrado Matías, Raúl author López-Jiménez, Rosa author Pérez, Diego author Huerta, Eva author Pérez, Mónica author Correa-Fiz, Florencia author Mancera-Gracia, José Carlos author Taylor, Lucas P. author Borowski, Stasia author Saunders, Gillian author Segalés Coma, Joaquim author López-Soria, Sergio author Balasch, Monica author 2022 Four studies under preclinical and clinical conditions were performed to evaluate the efficacy of a new trivalent vaccine against Porcine circovirus 2 (PCV-2) infection. The product contained inactivated PCV-1/PCV-2a (cPCV-2a) and PCV-1/PCV-2b (cPCV-2b) chimeras, plus M. hyopneumoniae inactivated cell-free antigens, which was administered to piglets in a two-dose regime at 3 days of age and 3 weeks later. The overall results of preclinical and clinical studies show a significant reduction in PCV-2 viraemia and faecal excretion, and lower histopathological lymphoid lesions and PCV-2 immunohistochemistry scores in vaccinated pigs when compared to non-vaccinated ones. Furthermore, in field trial A, a statistically significant reduction in the incidence of PCV-2-subclinical infection, an increase in body weight from 16 weeks of age to slaughterhouse and an average daily weight gain over the whole period (from 3 days of age to slaughterhouse) was detected in the vaccinated group when compared to the non-vaccinated one. Circulation of PCV-2a in field trial A, and PCV-2b plus PCV-2d in field trial B was confirmed by virus sequencing. In conclusion, a double immunization with a cPCV-2a/cPCV-2b/ M. hyopneumoniae vaccine was efficacious against PCV-2 infection by reducing the number of histopathological lymphoid lesions and PCV-2 detection in tissues, serum, and faeces, as well as reducing losses in productive parameters. Swine Porcine circovirus 2 Porcine circovirus 2-systemic disease Mycoplasma hyopneumoniae Porcine respiratory disease complex Trivalent vaccine Efficacy Efficacy Studies of a Trivalent Vaccine Containing PCV-2a, PCV-2b Genotypes and Mycoplasma hyopneumoniae When Administered at 3 Days of Age and 3 Weeks Later against Porcine Circovirus 2 (PCV-2) Infection