2026-04-17T10:37:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4626662026-03-13T10:19:32Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc David, Samuel author López Vales, Rubén author 2021 Altres ajuts: Fundació La Caixa LCF/TR/CI17/10020018 i LCF/PR/HA17/52170001; Canadian Institutes of Health Research MOP-142231; Wings for Life Spinal Cord Research Foundation, Red de Terapia Celular (TERCEL) Neuroinflammation is a prominent feature of the response to CNS trauma. It is also an important hallmark of various neurodegenerative diseases in which inflammation contributes to the progression of pathology. Inflammation in the CNS can contribute to secondary damage and is therefore an excellent therapeutic target for a range of neurological conditions. Inflammation in the nervous system is complex and varies in its fine details in different conditions. It involves a wide variety of secreted factors such as chemokines and cytokines, cell adhesion molecules, and different cell types that include resident cell of the CNS, as well as immune cells recruited from the peripheral circulation. Added to this complexity is the fact that some aspects of inflammation are beneficial, while other aspects can induce secondary damage in the acute, subacute and chronic phases. Understanding these aspects of the inflammatory profile is essential for developing effective therapies. Bioactive lipids constitute a large group ofmolecules that modulate the initiation and the resolution of inflammation. Dysregulation of these bioactive lipid pathways can lead to excessive acute inflammation, and failure to resolve this by specialized pro-resolution lipid mediators can lead to the development of chronic inflammation. The focus of this review is to discuss the effects of bioactive lipids in spinal cord trauma and their potential for therapies. Bioactive lipids Inflammation Omega-3 fatty acids Phospholipase A Prostaglandins Spinal cord injury Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury