2026-04-17T15:44:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4621162026-03-13T10:15:18Zcom_2072_98col_2072_378192

Low factor H-related 5 levels contribute to infection-triggered haemolytic uraemic syndrome and membranoproliferative glomerulonephritis Gómez Delgado, Irene Gutiérrez-Tenorio, Josué Fraga Rodríguez, Gloria María Cavero Escribano, Teresa Arjona, Emilia Sánchez-Corral, Pilar Universitat Autònoma de Barcelona CFHR5 Complement HCV HUS MPGN Streptococcus Pneumoniae Dysregulation of the alternative complement pathway is a major pathogenic mechanism in two rare renal diseases: atypical haemolytic uraemic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). We report on a 66-year-old male with chronic hepatitis C virus (HCV) infection and a combined liver-kidney transplant that was diagnosed with MPGN at the age of 63 years and a 5-year-old boy who presented with aHUS at the age of 21 months following a Streptococcus pneumoniae infection. Both patients carried similar frameshift variants in the complement CFHR5 gene that segregate with reduced levels of factor H-related 5 (FHR-5). We conclude that low FHR-5 levels may predispose to viral and bacterial infections that then trigger different renal phenotypes. 2020 Altres Ministerio de Economía y Competitividad PI16/00723 Ministerio de Economía, Industria y Competitividad SAF2014-52339P Ministerio de Economía y Competitividad BES-2015-073833 Clinical Kidney Journal ; Vol. 14 (march 2020), p. 707-709 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by-nc/4.0/