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oai:recercat.cat:2072/4621162026-03-13T10:15:18Zcom_2072_98col_2072_378192

Low factor H-related 5 levels contribute to infection-triggered haemolytic uraemic syndrome and membranoproliferative glomerulonephritis Gómez Delgado, Irene Gutiérrez-Tenorio, Josué Fraga Rodríguez, Gloria María Cavero Escribano, Teresa Arjona, Emilia Sánchez-Corral, Pilar Universitat Autònoma de Barcelona CFHR5 Complement HCV HUS MPGN Streptococcus Pneumoniae Dysregulation of the alternative complement pathway is a major pathogenic mechanism in two rare renal diseases: atypical haemolytic uraemic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). We report on a 66-year-old male with chronic hepatitis C virus (HCV) infection and a combined liver-kidney transplant that was diagnosed with MPGN at the age of 63 years and a 5-year-old boy who presented with aHUS at the age of 21 months following a Streptococcus pneumoniae infection. Both patients carried similar frameshift variants in the complement CFHR5 gene that segregate with reduced levels of factor H-related 5 (FHR-5). We conclude that low FHR-5 levels may predispose to viral and bacterial infections that then trigger different renal phenotypes. 2020 Altres https://ddd.uab.cat/record/258142 urn:10.1093/ckj/sfaa004 urn:oai:ddd.uab.cat:258142 urn:pmcid:PMC8962748 urn:pmc-uid:8962748 urn:pmid:35355886 urn:oai:pubmedcentral.nih.gov:8962748 urn:articleid:20488513v14p707 eng Ministerio de Economía y Competitividad PI16/00723 Ministerio de Economía, Industria y Competitividad SAF2014-52339P Ministerio de Economía y Competitividad BES-2015-073833 Clinical Kidney Journal ; Vol. 14 (march 2020), p. 707-709 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by-nc/4.0/ application/pdf