2026-04-17T06:47:03Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4621162026-03-13T10:15:18Zcom_2072_98col_2072_378192
RECERCAT author Gómez Delgado, Irene author Gutiérrez-Tenorio, Josué author Fraga Rodríguez, Gloria María author Cavero Escribano, Teresa author Arjona, Emilia author Sánchez-Corral, Pilar author Universitat Autònoma de Barcelona 2020 Dysregulation of the alternative complement pathway is a major pathogenic mechanism in two rare renal diseases: atypical haemolytic uraemic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). We report on a 66-year-old male with chronic hepatitis C virus (HCV) infection and a combined liver-kidney transplant that was diagnosed with MPGN at the age of 63 years and a 5-year-old boy who presented with aHUS at the age of 21 months following a Streptococcus pneumoniae infection. Both patients carried similar frameshift variants in the complement CFHR5 gene that segregate with reduced levels of factor H-related 5 (FHR-5). We conclude that low FHR-5 levels may predispose to viral and bacterial infections that then trigger different renal phenotypes. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by-nc/4.0/ CFHR5 Complement HCV HUS MPGN Streptococcus Pneumoniae Low factor H-related 5 levels contribute to infection-triggered haemolytic uraemic syndrome and membranoproliferative glomerulonephritis Altres