2026-04-13T13:43:37Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4618782024-11-04T03:55:49Zcom_2072_98col_2072_378192
RECERCAT author Enrich-Bengoa, Jennifer author Manich, Gemma author Valente, Tony author Sanchez-Molina, Paula author Almolda Ardid, Beatriz author Solà, Carme author Saura, Josep author González, Berta author Castellano López, Bernardo author Peralvarez-Marin, Alex author Universitat Autònoma de Barcelona. Institut de Neurociències 2024-11-04T03:55:49Z 2024-11-04T03:55:49Z 2022 http://hdl.handle.net/2072/461878 Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, which results from inflammation. Here we aim to characterize the expression and regulation of TRPV2 in myelination pathologies, such as hypomyelination and demyelination. We validated the interaction between TRPV2 and its putative interactor Opalin, an oligodendrocyte marker, in mixed glial cultures under pro- and anti-inflammatory conditions. Then, we characterized TRPV2 time-course expression in experimental animal models of hypomyelination (jimpy mice) and de-/remyelination (cuprizone intoxication and experimental autoimmune encephalomyelitis (EAE)). TRPV2 showed upregulation associated with remyelination, inflammation in cuprizone and EAE models, and downregulation in hypomyelinated jimpy mice. TRPV2 expression was altered in human samples of multiple sclerosis (MS) patients. Additionally, we analyzed the expression of methionine sulfoxide reductase A (MSRA), an enzyme that reduces oxidated methionines in TRPV2, which we found increased in inflammatory conditions. These results suggest that TRPV2 may be a key player in myelination in accordance with the recapitulation hypothesis, and that it may become an interesting clinical target in the treatment of demyelination disorders. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ Ransient potential receptor vanilloid 2 Opalin Oxidative stress Myelination Multiple sclerosis Recapitulation theory TRPV2 : a Key Player in Myelination Disorders of the Central Nervous System Article