2026-04-14T03:26:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4596102025-12-10T15:11:06Zcom_2072_98col_2072_378192

Meaning in life : resilience beyond reserve Bartrés-Faz, David Cattaneo, Gabriele Solana-Sánchez, Javier Tormos, Jose M. Pascual Leone, Álvaro Cognitive reserve Meaning in life Sense of coherence Purpose in life Cognition Affective status The research received funding from 'La Caixa' Foundation (grant agreement n° LCF/PR/PR16/11110004). The contribution of psychological factors to brain health and resilience remains poorly investigated. Furthermore, their possible interaction with 'classical' cognitive reserve (CR) estimates in predicting perceived mental health and cognitive status has not been specifically addressed. We obtained data from 1081 adults responding to questionnaires on the three meaning in life (MiL) dimensions: purpose in life (PiL), sense of coherence (SoC), and engagement with life (EwL). A questionnaire on CR variables was also administered. The outcome measures were self-reported cognitive function and affective status (depression, stress, and anxiety). Multiple linear regression analyses were used to evaluate the association between sociodemographic variables, MiL dimensions, and CR with the two selected outcomes. Mediation analyses, adjusted for age and gender, were applied to determine whether the MiL dimensions mediated the putative effects of CR on self-reported mental and cognitive health. All three MiL components, but not CR estimates, correlated with the self-reported affective status of the participants. Higher CR, PiL, and SoC (but not EwL) scores significantly correlated with higher perceived cognitive function. Notably, the observed association between the CR measures and self-reported cognitive function was mediated by PiL and SoC. Psychological MiL dimensions mediate the association between classic CR estimates and self-perceived cognitive function. Further studies on CR could consider including formal measures of such psychological factors to better understand their unique or synergistic contributions, as well as investigate the associated mechanisms maintaining brain function at older ages. The online version of this article (10.1186/s13195-018-0381-z) contains supplementary material, which is available to authorized users. 2018 Article https://ddd.uab.cat/record/253535 urn:10.1186/s13195-018-0381-z urn:oai:ddd.uab.cat:253535 urn:articleid:17589193v10 urn:pmcid:PMC5968537 urn:pmc-uid:5968537 urn:pmid:29793549 urn:oai:pubmedcentral.nih.gov:5968537 urn:scopus_id:85047613032 urn:oai:egreta.uab.cat:publications/05de4f13-0210-4a56-819f-715129de7979 eng Alzheimer's research & therapy ; Vol. 10 (may 2018) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ application/pdf