2026-04-13T04:34:50Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4594702026-03-13T08:04:49Zcom_2072_98col_2072_378192
RECERCAT author Biagetti, Betina author Herance, José Raul author Ferrer Costa, Roser author Aulinas, Anna author Palomino-Schätzlein, Martina author Mesa Manteca, Jordi author Castaño, Justo P. author Luque, Raul M. author Simó Canonge, Rafael author Universitat Autònoma de Barcelona 2019 Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated comorbidities. The present study was aimed at identifying metabolites that could be used as biomarkers for a better disease phenotyping. For this purpose, metabolic fingerprint using an untargeted metabolomic approach was examined in serum from 30 patients with acromegaly and 30 age-matched controls. Patients with acromegaly presented fewer branched-chain amino acids (BCAAs) compared to the control group (valine: 4.75 ± 0.87 vs. 5.20 ± 1.06 arbitrary units (AUs), p < 0.05; isoleucine: 2.54 ± 0.41 vs. 2.80 ± 0.51 AUs; p < 0.05). BCAAs were also lower in patients with active disease compared to patients with normal levels of IGF-1 with or without medical treatment. GH, but not IGF-1, serum levels were inversely correlated with both valine and isoleucine. These findings indicate that low levels of BCAAs represent the main metabolic fingerprint of acromegaly and that GH, rather than IGF-1, might be the primary mediator. In addition, our results suggest that the assessment of BCAAs could help to identify active disease and to monitor the response to therapeutic strategies. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ Acromegaly Metabolomics Amino acids Branched chain Insulin resistance Muscular weakness Metabolic Fingerprint of Acromegaly and Its Potential Usefulness in Clinical Practice Article