2026-04-17T01:45:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4591142025-04-03T06:59:52Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Fuentes Varela, Pedro author Sesé, Marta author Guijarro, Pedro J. author Emperador, Marta author Sánchez-Redondo, Sara author Peinado, Héctor author Hümmer, Stefan author Ramón y Cajal, Santiago author Universitat Autònoma de Barcelona author 2020 Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. We have now uncovered essential and thus far unknown roles of ITGB3 in vesicle uptake. The functional requirement for ITGB3 derives from its interactions with heparan sulfate proteoglycans (HSPGs) and the process of integrin endocytosis, allowing the capture of extracellular vesicles and their endocytosis-mediated internalization. Key for the function of ITGB3 is the interaction and activation of focal adhesion kinase (FAK), which is required for endocytosis of these vesicles. Thus, ITGB3 has a central role in intracellular communication via extracellular vesicles, proposed to be critical for cancer metastasis. The integrin ITGB3 has been described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. Here the authors describe thus far unknown roles of ITGB3 in the uptake of extracellular vesicles, required for colony growth of breast cancer cells Extracellular signalling molecules Mechanisms of disease Metastasis ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells