2026-04-18T08:02:08Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4587872026-03-13T07:57:49Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Umbria, Miriam author Ramos, Amanda author Aluja, Maria Pilar author Santos, Cristina author 2020 Recent studies associated certain type of cardiovascular disease (CVD) with specific mitochondrial DNA (mtDNA) defects, mainly driven by the central role of mitochondria in cellular metabolism. Considering the importance of the control region (CR) on the regulation of the mtDNA gene expression, the aim of the present study was to investigate the role of mtDNA CR mutations in two CVDs: stroke and myocardial infarction (MI). MtDNA CR mutations (both fixed and in heteroplasmy) were analysed in two demographically-matched case-control samples, using 154 stroke cases, 211 MI cases and their corresponding control individuals. Significant differences were found, reporting mutations m.16145 G. Genetic association study Risk factors The role of control region mitochondrial DNA mutations in cardiovascular disease : stroke and myocardial infarction