2026-04-13T04:09:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4587262026-03-13T07:57:21Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Ong, Hui Lin author Isvoranu, Adela-Maria author Schirmbeck, Frederike author McGuire, Philip author Valmaggia, Lucia author Kempton, Matthew author Gaag, Mark van der, 1953- author Riecher-Rössler, Anita author Bressan, Rodrigo Affonseca author Barrantes Vidal, Neus author Nelson, Barnaby author Amminger, G. Paul author McGorry, Patrick author Pantelis, Christos author Krebs, Marie Odile author Nordentoft, Merete author Glenthøj, Birte author Ruhrmann, Stephan author Sachs, Gabriele author Rutten, Bart P. F. author Os, Jim Van author Haan, Lieuwe de, 1960- author Borsboom, Denny author 2021 Altres ajuts: Medical Research Council Fellowship (MR/J008915/1); Netherlands Organization for Scientific Research (406.16.516) The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence. Network analysis Clinical high risk Psychosis Obsessive-compulsive Anxiety Depression Ultra-high risk Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis : A Network Perspective