2026-04-13T00:04:17Zhttps://recercat.cat/oai/requestoai:recercat.cat:2072/4587242026-03-13T07:57:20Zcom_2072_98col_2072_378192
00925njm 22002777a 4500
dc
Illán-Gala, Ignacio
author
Casaletto, Kaitlin B.
author
Borrego-Écija, Sergi
author
Arenaza-Urquijo, Eider
author
Wolf, Amy
author
Cobigo, Yann
author
Goh, Sheng Yang M.
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Staffaroni, Adam M.
author
Alcolea, Daniel
author
Fortea, Juan
author
Blesa, Rafael
author
Clarimón, Jordi
author
Iulita, M. Florencia
author
Brugulat-Serrat, Anna
author
Llado Plarrumani, Albert
author
Grinberg, Lea T.
author
Possin, Katherine
author
Rankin, Katherine P.
author
Kramer, Joel H.
author
Rabinovici, Gil D.
author
Boxer, Adam
author
Seeley, William W.
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Sturm, Virginia E.
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Gorno-Tempini, Maria Luisa
author
Miller, Bruce L.
author
Sanchez-Valle, Raquel
author
Perry, David C.
author
Lleó, Alberto
author
Rosen, Howard J.
author
Universitat Autònoma de Barcelona
author
2021
Altres ajuts: the "Marató TV3" grant (20141210 to JF, 044412 to RB, and 20143810 to RS-V), by Generalitat de Catalunya (PERIS SLT002/16/00408, PERIS SLT006/17/125 to DA, and SLT006/17/00119 to JF)
Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role in the behavioral variant of frontotemporal dementia (bvFTD) is unknown. We included 216 patients with bvFTD and 235 controls with magnetic resonance imaging (MRI) from a large multicenter cohort. We compared the clinical characteristics and cortical thickness between men and women with bvFTD and controls. We followed the residuals approach to study behavioral and cognitive reserve. At diagnosis, women with bvFTD showed greater atrophy burden in the frontotemporal regions compared to men despite similar clinical characteristics. For a similar amount of atrophy, women demonstrated better-than-expected scores on executive function and fewer changes in apathy, sleep, and appetite than men. Our findings suggest that women might have greater behavioral and executive reserve than men, and neurodegeneration must be more severe in women to produce symptoms similar in severity to those in men.
Cognitive reserve
Diagnosis
Frontotemporal dementia
Magnetic resonance imaging
Neuroimaging
Progression
Resilience
Survival
Sex differences in the behavioral variant of frontotemporal dementia : A new window to executive and behavioral reserve