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urn:hdl:2072/458724 Sex differences in the behavioral variant of frontotemporal dementia : A new window to executive and behavioral reserve Illán-Gala, Ignacio Casaletto, Kaitlin B. Borrego-Écija, Sergi Arenaza-Urquijo, Eider Wolf, Amy Cobigo, Yann Goh, Sheng Yang M. Staffaroni, Adam M. Alcolea, Daniel Fortea, Juan Blesa, Rafael Clarimón, Jordi Iulita, M. Florencia Brugulat-Serrat, Anna Llado Plarrumani, Albert Grinberg, Lea T. Possin, Katherine Rankin, Katherine P. Kramer, Joel H. Rabinovici, Gil D. Boxer, Adam Seeley, William W. Sturm, Virginia E. Gorno-Tempini, Maria Luisa Miller, Bruce L. Sanchez-Valle, Raquel Perry, David C. Lleó, Alberto Rosen, Howard J. Universitat Autònoma de Barcelona Cognitive reserve Diagnosis Frontotemporal dementia Magnetic resonance imaging Neuroimaging Progression Resilience Survival Altres ajuts: the "Marató TV3" grant (20141210 to JF, 044412 to RB, and 20143810 to RS-V), by Generalitat de Catalunya (PERIS SLT002/16/00408, PERIS SLT006/17/125 to DA, and SLT006/17/00119 to JF) Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role in the behavioral variant of frontotemporal dementia (bvFTD) is unknown. We included 216 patients with bvFTD and 235 controls with magnetic resonance imaging (MRI) from a large multicenter cohort. We compared the clinical characteristics and cortical thickness between men and women with bvFTD and controls. We followed the residuals approach to study behavioral and cognitive reserve. At diagnosis, women with bvFTD showed greater atrophy burden in the frontotemporal regions compared to men despite similar clinical characteristics. For a similar amount of atrophy, women demonstrated better-than-expected scores on executive function and fewer changes in apathy, sleep, and appetite than men. Our findings suggest that women might have greater behavioral and executive reserve than men, and neurodegeneration must be more severe in women to produce symptoms similar in severity to those in men. 2021 Article Ministerio de Economía y Competitividad PI14/01126 Instituto de Salud Carlos III PI17/01019 Ministerio de Economía y Competitividad PI13/01532 Ministerio de Economía y Competitividad PI16/01825 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III INT19/00016 Instituto de Salud Carlos III PI18/00435 Ministerio de Economía y Competitividad PI15/01618 Instituto de Salud Carlos III PI14/1561 Instituto de Salud Carlos III PI18/00326 Ministerio de Economía y Competitividad AC14/00013 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III CM17/00074 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-0235 Alzheimer's & dementia ; Vol. 17 (february 2021), p. 1329-1341 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/