2026-04-18T07:54:54Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4583532024-11-01T00:55:23Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Qin, Liyun author Guitart, Maria author Admetlló, Mireia author Esteban-Cucó, Sandra author Maiques, José María author Xia, Yingchen author Zha, Jianhua author Carbullanca, Santiago author Duran-Jordà, Xavier author Wang, Xuejie author Barreiro, Esther author Universitat Autònoma de Barcelona author 2021 We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place and correlate with clinical parameters. In plasma samples from patients with very mild bronchiectasis, inflammatory cells and molecules and redox balance parameters were analyzed. In the patients, lung function and exercise capacity, nutritional status, bacterial colonization, and radiological extension were assessed. Correlations between biological and clinical variables were determined. Compared to healthy controls, levels of acute phase reactants, neutrophils, IgG, IgA, myeloperoxidase, protein oxidation, and GSH increased and lung function and exercise capacity were mildly reduced. GSH levels were even greater in ex-smoker and Pseudomona-colonized patients. Furthermore, radiological extension inversely correlated with airway obstruction and, disease severity, and positively correlated with neutrophil numbers in mild bronchiectasis patients with no nutritional abnormalities. In stable patients with mild bronchiectasis, several important inflammatory and oxidative stress events take place in plasma. These findings suggest that the extension of bronchiectasis probably plays a role in the development of redox imbalance and systemic inflammation in patients with mild bronchiectasis. These results have therapeutic implications in the management of bronchiectasis patients. http://hdl.handle.net/2072/458353 Non-CF bronchiectasis patients Prooxidants Antioxidants Acute phase reactants Myeloperoxidase Reduced glutathione Bronchiectasis severity scores Do redox balance and inflammatory events take place in mild bronchiectasis? A hint to clinical implications